2024/2025Artículo donadores GC ATM exón 50 y PALB2 exón 12Ines Llinares BurguetNovel imaging tools to study mitochondrial morphology in Caenorhabditis elegansSilvia Romero SanzDOI: 10.26508/lsa.202402918 2023/2024Pharmacological activation of insulin-degrading enzymeimproves insulin secretion and glucose tolerancein diet-induced obese miceAlba Sanz GonzalezSynergistic impact of N-antigenemia profiled by a rapid antigen test and low anti-S1 antibodies on the risk of hospitalization in COVID-19Amanda De la Fuente VazquezPUBLICACION COMO PRIMERA AUTORA Synergistic impact of innate immunity hyper-activation and endothelial dysfunction on the magnitude of organ failure in the infection-sepsis continuumAmanda De la Fuente VazquezPUBLICACION COMO PRIMERA AUTORA Publicación de un artículo en la revista Frontiers in ImmunologyCristina Aparicio FernándezPublicación de un artículo titulado "MRGPRX2 signaling involves the Lysyl-tRNA synthetase and MITF pathway" en la revista Frontiers in Immunology. (DOI: 10.3389/fimmu.2023.1154108) (https://www.frontiersin.org/articles/10.3389/fimmu.2023.1154108/full) Publicación de un artículo en la revista International Journal of Molecular SciencesCristina Aparicio FernándezPublicación de la revisión "MITF Downregulation Induces Death in Human Mast Cell Leukemia Cells and Impairs IgE-Dependent Degranulation" perteneciente al número especial Mast Cells: From Host Defense to Pathology 2.0 de la revista International Journal of Molecular Sciences. (DOI: 10.3390/ijms24043515) (https://www.mdpi.com/1422-0067/24/4/3515) Publicación Segundo AutorDaniel Barriuso PalaciosPublicación Tercer AutorDaniel Barriuso PalaciosArticulo: The mitochondrial signature of cultured endothelial cells in sepsis: Identifying potential targets for treatmentDino Joaquín GobelliArticulo: Development of a novel in vitro model to study the modulatory role of the respiratory complex I in macrophage effector functionsDino Joaquín GobelliUsing C. elegans as a model for neurodegenerative diseases: Methodology and evaluationElena Caldero EscuderoUsing C. elegans as a model for neurodegenerative diseases: Methodology and evaluation https://doi.org/10.1016/bs.mcb.2024.03.004 SERCA inhibition improves lifespan and healthspan in a chemical model of Parkinson disease in Caenorhabditis elegans (PAPER)Elena Caldero EscuderoDOI 10.3389/fphar.2023.1182428 Chronic N-acetyl cysteine treatment does not improve respiratory system performance in the mdx mouse model of Duchenne muscular dystrophyEsther Valverde PérezPulmonary Vascular Responses to Chronic Intermittent Hypoxia in a Guinea Pig model of Obstructive Sleep ApneaEsther Valverde PérezArtículo CHEK2Ines Llinares BurguetArtículo CHEK2 E8&E10Ines Llinares BurguetAging AdipoR2-deficient mice are hyperactive with enlarged brains excessively rich in saturated fatty acidsJorge Mondejar DuranRuiz M, Devkota R, Bergh PO, et al. Aging AdipoR2-deficient mice are hyperactive with enlarged brains excessively rich in saturated fatty acids. FASEB J. 2024;38(14):e23815. doi:10.1096/fj.202400293RR Obesity-Associated Colorectal CancerLucía Álvarez FrutosMultiomics insights on the onset, progression, and metastatic evolution of breast cancerLucía Álvarez FrutosInvolvement of Bcl-2 Family Proteins in Tetraploidization-Related SenescenceLucía Álvarez FrutosDevelopment of a novel in vitro model to study the modulatory role of the respiratory complex I in macrophage effector functions.Maria Jesus Esteban AmoSerrano-Lorenzo, P., Gobelli, D., Garrido-Moraga, R., Esteban-Amo, M. J., López-López, J. R., Orduña, A., de la Fuente, M. A., Martín, M. A., & Simarro, M. Development of a novel in vitro model to study the modulatory role of the respiratory complex I in macrophage effector functions. En: PLOS ONE. 19/09/2023, 18(9), e0291442. https://doi.org/10.1371/journal.pone.0291442 The mitochondrial succinate dehydrogenase complex controls the STAT3-IL-10 pathway in inflammatory macrophages.Maria Jesus Esteban AmoGobelli, D., Serrano-Lorenzo, P., Esteban-Amo, M. J., Serna, J., Pérez-García, M. T., Orduña, A., Jourdain, A. A., Martín-Casanueva, M., Á. de la Fuente, M., & Simarro, M. The mitochondrial succinate dehydrogenase complex controls the STAT3-IL-10 pathway in inflammatory macrophages. En: IScience. 18/08/2023, 26(8), 107473. https://doi.org/10.1016/J.ISCI.2023.107473 Artículo titulado "Profiling of the genetic features of patients with breast, ovarian, colorectal and extracolonic cancers: Association to CHEK2 and PALB2 germline mutations", publicado en la revista Clinica Chimica Acta.Mónica Arranz Ledohttps://doi.org/10.1016/j.cca.2023.117695 Participación en la publicación titulada "SpadaHC: a database to improve the classification of variants in hereditary cancer genes in the Spanish population", publicada en la revista DatabaseMónica Arranz LedoA Missense Variant in TP53 Could Be a Genetic Biomarker Associated with Bone Tissue AlterationsNadia Regina Galindo CabelloAutores: Ricardo Usategui-Martín, Nadia Galindo-Cabello, Salvador Pastor-Idoate, José María Fernández-Gómez, Álvaro del Real, Diego Ferreño, Rebeca Lapresa, Francisco Martín-Rodriguez, José A. Riancho, Ángeles Almeida, and José Luis Pérez-Castrillón Revista: International Journal of Molecular Sciences ABSTRACT: Frequent TERT gains in metastatic papillary thyroid carcinoma - Annals Of OncologySara Gil BernabéPublicación del Abstract del Póster presentado al Congreso ESMO 2023. Frequent TERT gains in metastatic papillary thyroid carcinoma. Annals of Oncology (2023) 34 (suppl_2): S1145-S1151. 10.1016/annonc/annonc1309 IF(2022):50.5 Using C. elegans as a model for neurodegenerative diseases: Methodology and evaluationSilvia Romero Sanzhttps://doi.org/10.1016/bs.mcb.2024.03.004 Publicación científicaTeresa Garrido Garcia2022/2023A novel orthotopic mouse model replicates human lung cancer cachexia (https://pubmed.ncbi.nlm.nih.gov/37025071/)Alba Sanz GonzalezEffect of viral storm in patients admitted to intensive care units with severe COVID-19 in Spain: a multicentre, prospective, cohort studyAmanda De la Fuente VazquezPublicación de una revisión en la revista Experimental Hematology & OncologyCristina Aparicio FernándezPublicación de la revisión "Current approaches to develop off-the-shelf chimeric antigen receptor (CAR)-T cells for cancer treatment: a systematic review" en la revista Experimental Hematology & Oncology (https://doi.org/10.1186/s40164-023-00435-w) (https://ehoonline.biomedcentral.com/articles/10.1186/s40164-023-00435-w). Publicación como primer autor en PaperDaniel Barriuso PalaciosArticle The mitochondrial succinate dehydrogenase complex controls the STAT3 IL-10 pathway in inflammatory macrophagesDino Joaquín GobelliSLC25A46 promotes mitochondrial fission and mediates resistance to lipotoxic stress in INS-1E insulin-secreting cellsElena Caldero EscuderoSLC25A46 promotes mitochondrial fission and mediates resistance to lipotoxic stress in INS-1E insulin-secreting cells. DOI: 10.1242/jcs.260049 Effects of Gestational Intermittent Hypoxia on Placental Morphology and Fetal Development in a Murine Model of Sleep Apnea.Esther Valverde PérezDOI : 10.1007/978-3-031-32371-3 (Estimated Print Publication Date:Jul-2023). Intermittent Hypoxia and Diet-Induced Obesity on the Intestinal Wall Morphology in a Murine Model of Sleep ApneaEsther Valverde PérezDOI : 10.1007/978-3-031-32371-3 (Estimated Print Publication Date:Jul-2023). Colaboración en el paper de título: Anti-Neuroinflammatory Potential of a Nectandra angustifolia (Laurel Amarillo) Ethanolic ExtractHugo Calvo VecinoArtículo PALB2Ines Llinares BurguetDual role of Apolipoprotein D as long-term instructive factor and acute signal conditioning microglial secretory and phagocytic responsesJorge Mondejar DuranDual role of Apolipoprotein D as long-term instructive factor and acute signal conditioning microglial secretory and phagocytic responses 10.3389/fncel.2023.1112930 Splicing Analysis of 16 PALB2 ClinVar Variants by Minigene Assays: Identification of Six Likely Pathogenic VariantsLara Sanoguera MirallesPublicación IJMS - MDPILaura Sanchez SanchezCharacterization of the Antitumor Potential of Extracts of Cannabis sativa Strains with High CBD Content in Human NeuroblastCharacterization of the Antitumor Potential of Extracts of Cannabis sativa Strains with High CBD Content in Human Neuroblastomaoma Antioxidants IJMSLaura Sanchez SanchezProtective Actions of α-Tocopherol on Cell Membrane Lipids of Paraquat-Stressed Human Astrocytes Using Microarray Technology, MALDI-MS and Lipidomic Analysis Publicación Cientifica en Revista Cancers"Transcriptional Basis of Ca2+ Remodeling Reversal Induced by Polyamine Synthesis Inhibition in Colorectal Cancer Cells"María Elena Hernando PérezShort communication "Multigene germline testing usefulness instead of BRCA1/2 single screening in triple negative breast cancer cases" publicado en la revista "Pathology - Research and Practice", posicionada en Q2.Mónica Arranz LedoA Large Case-Control Study Performed in Spanish Population Suggests That RECQL5 Is the Only RECQ Helicase Involved in Breast Cancer SusceptibilityMónica Arranz LedoParticipación en el trabajo, titulado "A Large Case-Control Study Performed in Spanish Population Suggests That RECQL5 Is the Only RECQ Helicase Involved in Breast Cancer Susceptibility", publicado en la revista Cancers el 28 de septiembre de 2022. Anti-Neuroinflammatory Potential of a Nectandra angustifolia (Laurel Amarillo) Ethanolic ExtractMónica Macías PanedasIncreased Co-Occurrence of Pathogenic Variants in Hereditary Breast and Ovarian Cancer and Lynch Syndromes: A Consequence of Multigene Panel Genetic Testing?Mónica Arranz LedoParticipación en el trabajo, titulado "Increased Co-Occurrence of Pathogenic Variants in Hereditary Breast and Ovarian Cancer and Lynch Syndromes: A Consequence of Multigene Panel Genetic Testing?", que fue publicado en la revista International Journal of Molecular Sciences el 29 de septiembre de 2022. PUBLICACIÓN CAPÍTULO DE LIBRO: Renin-Angiotensin-Aldosterone System in Neurodegenerative Retinal DisordersNadia Regina Galindo CabelloTítulo de la publicación: Renin-Angiotensin-Aldosterone System in Neurodegenerative Retinal Disorders Autores: Nadia Galindo Cabello; Salvador Pastor Idoate; Ricardo Usategui Martin. Libro: Horizons in Neuroscience Research. 49 - 979-8-88697-676-2, Nova Science Publishers. ISSN 1552-5783 Publicación artículo: "Silk-Elastin-like Polymers for Acute Intraparenchymal Treatment of the Traumatically Injured Spinal Cord: A First Systematic Experimental Approach"Sara Escalera AnzolaGonzález, P.; González-Fernández, C.; Maqueda, A.; Pérez, V.; Escalera-Anzola, S.; Rodríguez de Lope, Á.; Arias, F.J.; Girotti, A.; Rodríguez, F.J. Silk-Elastin-like Polymers for Acute Intraparenchymal Treatment of the Traumatically Injured Spinal Cord: A First Systematic Experimental Approach. Pharmaceutics 2022, 14, 2713. https://doi.org/10.3390/pharmaceutics14122713 ABSTRACT: CREBBP/EP300 disruption promotes tumor progression and confers synthetic lethality in anaplastic thyroid cancers.Sara Gil BernabéPublicación del Abstract presentado en el AACR Annual Meeting 2023 en la revista Cancer Research. DOI: https://doi.org/10.1158/1538-7445.AM2023-3068 Characterization of endogenous Kv1.3 channel isoforms in T cellsSara Moreno EstarSERCA inhibition improves lifespan and healthspan in a chemical model of Parkinson disease in Caenorhabditis elegansSilvia Romero SanzEnlace a la dirección del repositorio: https://www.frontiersin.org/articles/10.3389/fphar.2023.1182428/full SLC25A46 promotes mitochondrial fission and mediates resistance to lipotoxic stress in INS-1E insulin-secreting cellsSilvia Romero SanzEnlace a la dirección del repositorio: https://journals.biologists.com/jcs/article-abstract/136/8/jcs260049/307067/SLC25A46-promotes-mitochondrial-fission-and?redirectedFrom=fulltext Transcriptional Basis of Ca2+ Remodeling Reversal Induced by Polyamine Synthesis Inhibition in Colorectal Cancer CellsVerónica Feijóo SalgadoPublicación del artículo "Transcriptional Basis of Ca2+ Remodeling Reversal Induced by Polyamine Synthesis Inhibition in Colorectal Cancer Cells" en la revista Cancers. https://doi.org/10.3390/cancers15051600 2021/2022Splicing predictions, minigene analyses and ACMG/AMP clinical classification of 42 germline PALB2 splice-site variantsALBERTO VALENZUELA PALOMOPUBLICACIÓN UTILIZADA COMO AVAL DE TESIS Low anti-SARS-CoV-2 S antibody levels predict increased mortality and dissemination of viral components in the blood of critical COVID-19 patientsAmanda De la Fuente VazquezPublicación científica N-antigenemia detection by a rapid lateral flow test predicts 90-day mortality in COVID-19: a prospective cohort studyAmanda De la Fuente VazquezPublicación científica en Clinical Microbiology and Infection. Digital PCR applications for the diagnosis and management of infection in critical care medicineAmanda De la Fuente VazquezPablos M, Casanueva-Álvarez E, González-Casimiro CM, Merino B, Perdomo G, Cózar-Castellano I. Primary Cilia in Pancreatic β- and α-Cells: Time to Revisit the Role of Insulin-Degrading Enzyme. Front Endocrinol (Lausanne). 2022 Jun 27;13:922825. doi: 10.3389/fendo.2022.922825. PMID: 35832432; PMCID: PMC9271624.Carlos Manuel González CasimiroGonzález-Casimiro, C.M.; Cámara-Torres, P.; Merino, B.; Diez-Hermano, S.; Postigo-Casado, T.; Leissring, M.A.; Cózar-Castellano, I.; Perdomo, G. Effects of Fasting and Feeding on Transcriptional and Posttranscriptional Regulation of Insulin-Degrading Enzyme in Mice. Cells 2021, 10, 2446. https://doi.org/10.3390/cells10092446Carlos Manuel González CasimiroMerino B, Casanueva-Álvarez E, Quesada I, González-Casimiro CM, Fernández-Díaz CM, Postigo-Casado T, Leissring MA, Kaestner KH, Perdomo G, Cózar-Castellano I. Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation. Diabetologia. 2022 Aug;65(8):1375-1389. doi: 10.1007/s00125-022-05729-y. Epub 2022 Jun 2. PMID: 35652923; PMCID: PMC9283140.Carlos Manuel González CasimiroPublicación de una revisión en la revista International Journal of Molecular SciencesCristina Aparicio FernándezPublicación de la revisión "Cell Therapy for Colorectal Cancer: The Promise of Chimeric Antigen Receptor (CAR)-T Cells" perteneciente al número especial Colorectal Cancer: From Pathophysiology to Novel Therapeutic Approaches 2021 de la revista International Journal of Molecular Sciences (https://doi.org/10.3390/ijms222111781) (https://www.mdpi.com/1422-0067/22/21/11781). Roles of Palmitoleic Acid and Its Positional Isomers, Hypogeic and Sapiencia, in Inflammation, Metabolic Diseases and Cancer. Cells, 2022.Cristina Fraile SánchezFungal Patterns Induce Cytokine Expression through Fluxes of Metabolic Intermediates That Support Glycolysis and Oxidative PhosphorylationCristina Mancebo TejeraPublicación en revista: The journal of immunology https://www.jimmunol.org/content/early/2022/06/10/jimmunol.2100666 Capítulo de libro: Designing Elastin-Like Recombinamers for Therapeutic and Regenerative PurposesDiana Juanes GusanoPaper "Self-assembling systems comprising intrinsically disordered protein polymers like elastin-like recombinamers"Diana Juanes GusanoSystematic Analysis of FASTK Gene Family Alterations in CancerDino Joaquín GobelliPrimary Cilia in Pancreatic b- and a-Cells: Time to Revisit the Role of Insulin-Degrading EnzymeElena Casanueva ÁlvarezInsulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation.Elena Casanueva ÁlvarezDiabetologia 2022. Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortalityElisa Arribas RodríguezA first update on mapping the human genetic architecture of COVID-19 genetic architecture of COVID-19Elisa Arribas RodríguezPublicado en la revista Nature el 03 de agosto de 2022 Publicación artículo RAD51CInes Llinares BurguetPublicación artículo ATMInes Llinares BurguetpublicaciónJose Javier Fernandez RodriguezPUBLICACIÓN: CRISPR/CasRx Proof-of-Concept for RNA Degradation: A Future Tool against RNA Viruses'Julia Serna PerezPharmaceuticals 2022, 15(1), 32; https://doi.org/10.3390/ph15010032 "Minigene-based splicing analysis and ACMG/AMP-based tentative classification of 56 ATM variants"Lara Sanoguera MirallesMinigene Splicing Assays Identify 20 Spliceogenic Variants of the Breast Ovarian Cancer Susceptibility Gene RAD51CLara Sanoguera Miralles"Splicing predictions, minigene analyses and ACMG/AMP clinical classification of 42 germline PALB2 splice-site variants"Lara Sanoguera Miralles"Germline Variants of CYBA and TRPM4 Predispose to Familial Colorectal Cancer"Lara Sanoguera MirallesAnalysis of mitochondrial function in cell membranes as indicator of tissue vulnerability to drugs in humansLaura Sanchez SanchezPublicación de artículo en la revista Biomedicines PAPER REMODELING OF INTRACELLULAR Ca2+HOMEOSTASIS IN RAT HIPPOCAMPASL NEURONS AGED IN VITROMaría Elena Hernando PérezARTICULO/REVIEW: REMODELING OF INTRACELLULAR Ca2+ HOMEOSTASIS IN RAT HIPPOCAMPAL NEURONS AGED IN VITRO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.24 FEBRUARY 2020 PUBLICACION EN LA REVISTA CIENTIFICA BIOMEDICINES " AMYLOID BETA OLIGOMERS-INDUCED Ca2+ ENTRY PATHWAYS: ROLE OF NEURONAL NETWORKS, NMDA RECEPTORS AND AMYLOID CHANNEL FORMATION". BIOMEDICNES 2022, 10,1153.María Elena Hernando PérezPAPER REMODELING OF INTRACELLULAR Ca2+HOMEOSTASIS IN RAT HIPPOCAMPASL NEURONS AGED IN VITROMaría Elena Hernando PérezARTICULO/REVIEW: REMODELING OF INTRACELLULAR Ca2+ HOMEOSTASIS IN RAT HIPPOCAMPAL NEURONS AGED IN VITRO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.24 FEBRUARY 2020 PAPER REMODELING OF INTRACELLULAR Ca2+HOMEOSTASIS IN RAT HIPPOCAMPASL NEURONS AGED IN VITROMaría Elena Hernando PérezARTICULO/REVIEW: REMODELING OF INTRACELLULAR Ca2+HOMEOSTASIS IN RAT HIPPOCAMPASL NEURONS AGED IN VITRO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.24 FEBRUARY 2020 Programmed cell death and autophagy during retinal neurodegenerationNadia Regina Galindo CabelloK.Puertas Neyra; N. Galindo Cabello; L. Hernández Rodríguez; F. González Pérez; J.C. Rodriguez Cabello; R. González Sarmiento; J.C. Pastor; R. Usategui Martin; I. Fernandez Bueno.Programmed cell death and autophagy during retinal neurodegeneration.2022,v16.,pp1-14.10.3389/fnana.2022.812487 Retinal Neuroprotective Effect of Mesenchymal Stem Cells Secretome Through Modulation of Oxidative Stress, Autophagy, and Programmed Cell DeathNadia Regina Galindo CabelloR. Usategui Martin; K. Puertas Neyra; N. Galindo Cabello; L. Hernández Rodríguez; F. González Pérez; J.C. Rodriguez Cabello; R. González Sarmiento; J.C. Pastor; I. Fernandez Bueno. Retinal Neuroprotective Effect of Mesenchymal Stem Cells Secretome Through Modulation of Oxidative Stress, Autophagy, and Programmed Cell Death.2022,v.63,n°4,pp27. https://doi.org/10.1167/iovs.63.4.27 Publicación revisiónNuria Daghbouche RubioAutora paper: Effects of Fasting and Feeding on Transcriptional and Posttranscriptional Regulation of Insulin-Degrading Enzyme in MicePatricia Cámara TorresPublicación Capítulo de libro "Designing Elastin-Like Recombinamers for Therapeutic and Regenerative Purposes"Sara Escalera AnzolaRodríguez-Cabello, J.C., Escalera ☆ , S., Juanes-Gusano ☆ , D., Santos, M. and Girotti, A. (2022). Designing Elastin-Like Recombinamers for Therapeutic and Regenerative Purposes. In Multifunctional Hydrogels for Biomedical Applications (eds R.A. Pires, I. Pashkuleva and R.L. Reis). https://doi.org/10.1002/9783527825820.ch3 Publicación capítulo de libro "Elastin-like Polymers as Nanovaccines: Protein Engineering of Self-Assembled, Epitope-Exposing Nanoparticles"Sara Escalera AnzolaGirotti, A., González-Valdivieso, J., Alonso-Sampedro, I., Escalera-Anzola, S., Ramos-Díez, S., Arias, F.J. (2022). Elastin-like Polymers as Nanovaccines: Protein Engineering of Self-Assembled, Epitope-Exposing Nanoparticles. In: Brun, A. (eds) Vaccine Technologies for Veterinary Viral Diseases. Methods in Molecular Biology, vol 2465. Humana, New York, NY. Remodeling of Intracellular Ca2+ Homeostasis in Rat Hippocampal Neurons Aged In VitroSara López VázquezCalvo-Rodríguez M, Hernando-Pérez E, López-Vázquez S, Núñez L, Villalobos C, Intracellular calcium remodeling in rat hippocampal neurons aged in vitro, International Journal of Molecular Sciences, 2020, doi: 10.3390/ijms21041549, Q1 IF: 4,3. Publicación Revisión "Aptamer-Functionalized Natural Protein-Based Polymers as Innovative Biomaterials"Sara Escalera AnzolaGirotti, A.; Escalera-Anzola, S.; Alonso-Sampedro, I.; González-Valdivieso, J.; Arias, F.J. Aptamer-Functionalized Natural Protein-Based Polymers as Innovative Biomaterials. Pharmaceutics 2020, 12, 1115. https://doi.org/10.3390/pharmaceutics12111115 ABSTRACT: A comprehensive study of the role of EIF1AX mutations in anaplastic thyroid carcinomas. Relationship with established mutational events, tumor progression and dedifferentiationSara Gil BernabéPublicación del Abstract del Congreso ESMO 2021 en Annals of Oncology IF: 32.976 (2020). Publicacion en The FEBS Journal: "Clinically used JAK inhibitor blunts dsRNA-induced inflammation and calcification in aortic valve interstitial cells" en el cual soy primera autora junto con Iván Parra-izquierdo (*=coautoría)Tania Sánchez-Bayuela RecioPublicacion en The FEBS Journal: "Clinically used JAK inhibitor blunts dsRNA-induced inflammation and calcification in aortic valve interstitial cells" en el cual soy primera autora junto con Iván Parra-izquierdo (*=coautoría) https://pubmed.ncbi.nlm.nih.gov/34009721/ Publicación en International Journal of Molecular Sciences. "Interferons Are Pro-Inflammatory Cytokines in Sheared-Stressed Human Aortic Valve Endothelial Cells"Tania Sánchez-Bayuela RecioPublicación en International Journal of Molecular Sciences. "Interferons Are Pro-Inflammatory Cytokines in Sheared-Stressed Human Aortic Valve Endothelial Cells" https://pubmed.ncbi.nlm.nih.gov/34638942/ 2020/2021Colaboración en la publicación de un artículo científicoAida Fiz LópezMorales, A. et al. Growth arrest-specific factor 6 (Gas6) is increased in covid-19 patients and predicts clinical outcome. Biomedicines 9, 111 (2021). Viral RNA load in plasma is associated with critical illness and a dysregulated host response in COVID-19. Bermejo‑Martin et al. Crit Care (2020) 24:691 https://doi.org/10.1186/s13054‑020‑03398‑0Amanda De la Fuente VazquezMounting evidence of impaired viral control in severe COVID-19.Lancet Microbe 2021 Published Online April 15, 2021 https://doi.org/10.1016/ S2666-5247(21)00084-7Amanda De la Fuente VazquezA host transcriptomic signature for identification of respiratory viral infections in the communityAmanda De la Fuente VazquezThe COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity. Lancet Respir Med 2021 Published Online May 6, 2021 https://doi.org/10.1016/S2213-2600(21)00218-6Amanda De la Fuente VazquezLeissring, M.A.; González-Casimiro, C.M.; Merino, B.; Suire, C.N.; Perdomo, G. Targeting Insulin-Degrading Enzyme in Insulin Clearance. Int. J. Mol. Sci. 2021, 22, 2235. https://doi.org/10.3390/ijms22052235Carlos Manuel González CasimiroGonzález-Casimiro, C.M.; Merino, B.; Casanueva-Álvarez, E.; Postigo-Casado, T.; Cámara-Torres, P.; Fernández-Díaz, C.M.; Leissring, M.A.; Cózar-Castellano, I.; Perdomo, G. Modulation of Insulin Sensitivity by Insulin-Degrading Enzyme. Biomedicines 2021, 9, 86. https://doi.org/10.3390/biomedicines9010086Carlos Manuel González CasimiroPublicación: Novel fluorescent-based reporter cell line engineered for monitoring homologous recombination eventsDino Joaquín GobelliModulation of Insulin Sensitivity by Insulin-Degrading Enzyme (Biomedicines)Elena Casanueva ÁlvarezHuman intestinal dendritic cell and macrophage subsets in coeliac diseaseElisa Arribas RodríguezEvaluation of Cytokines as Robust Diagnostic Biomarkers for COVID-19 DetectionElisa Arribas RodríguezGrowth Arrest-Specific Factor 6 (GAS6) Is Increased in COVID-19 Patients and Predicts Clinical OutcomeElisa Arribas RodríguezArtículo CientíficoJorge Rojo MencíaPublicación: Novel fluorescent-based reporter cell line engineered for monitoring homologous recombination eventsJulia Serna PerezBernardi A, Gobelli D, Serna J, Nawrocka P, March-Rosselló G, Orduña A, Kozlowski P, Simarro M, de la Fuente MA. Novel fluorescent-based reporter cell line engineered for monitoring homologous recombination events. PLoS One. 2021 Apr 30;16(4):e0237413. doi: 10.1371/journal.pone.0237413. PMID: 33930025; PMCID: PMC8087102. RAD51D Aberrant Splicing in Breast Cancer: Identification of Splicing Regulatory Elements and Minigene-Based Evaluation of 53 DNA VariantsLara Sanoguera Miralles"Comprehensive Functional Characterization and Clinical Interpretation of 20 Splice-Site Variants of the RAD51C Gene"Lara Sanoguera MirallesPublicación científicaMIGUEL ANGEL BERMUDEZ ARIASPublicación científica como coautor del artículo: Astudillo, A.M., Meana, C., Bermúdez, M.A., Pérez-Encabo, A., Balboa, M.A. & Balsinde, J. (2020) Release of anti-inflammatory palmitoleic acid and its positional isomers by mouse peritoneal macrophages. Biomedicines 8: 480. Publicación trabajo en revista de investigación (Trabajo final de máster)Nuria Daghbouche RubioAutora en review publicada en Metabolism: "Modulation of insulin sensitivity by insulin-degrading enzyme"Patricia Cámara TorresAbstract PO-005: Spatio-temporal geographical molecular mapping of primary papillary thyroid carcinomas and paired distant metastases: Clinical relevance for monitoring and targeting tumor heterogeneitySara Gil BernabéTipo de comunicación: Virtual Poster Congreso: Virtual Special Conference: Tumor Heterogeneity: From Single Cells to Clinical Impact Entidad organizadora: AACR (American Association for Cancer Research) DOI: 10.1158/1538-7445.TUMHET2020-PO-005 Fecha de publicación: Noviembre 2020 Revista: Cancer Research Factor de Impacto: 12.701 (2020) Publicacion revista Molecular MetabolismSara Moreno EstarPublicación en FEBS. "Clinically used JAK inhibitor blunts dsRNA-induced inflammation and calcification in aortic valve interstitial cells"Tania Sánchez-Bayuela RecioPublicación en FEBS: "Clinically used JAK inhibitor blunts dsRNA-induced inflammation and calcification in aortic valve interstitial cells" Ivan Parra-Izquierdo* , Tania Sanchez-Bayuela*, Irene Casta~nos-Mollor, Javier Lopez, Cristina Gomez1, J. Alberto San Roman, Mariano Sanchez Crespo and Carmen Garcıa-Rodrıguez. *coautores 2019/2020First Person InterviewALBA DEL RÍO LORENZOSarcoplasmic reticulum Ca2+ decreases with age and correlates with the decline in muscle function in DrosophilaALBA DEL RÍO LORENZOUGT1A1 Variants c.864+5G>T and c.996+2_996+5del of a Crigler-Najjar Patient Induce Aberrant Splicing in Minigene AssaysALBERTO VALENZUELA PALOMOB. Merino, C.M. Fernández-Díaz, C. Parrado-Fernández, et al., Hepatic insulin-degrading enzyme regulates glucose and insulin homeostasis in diet induced obese mice, Metabolism (2020), https://doi.org/10.1016/j.metabol.2020.154352Carlos Manuel González CasimiroMR- proADM to detect specific types of organ failure in infection.CRISTINA ANDRES LEDESMAPublicación en la revista European Journal of Clinical Investigation Reporte SEI Sociedad Española InmunologíaJose Javier Fernandez RodriguezPublicación: Myocardin-Dependent Kv1.5 Channel Expression Prevents Phenotypic Modulation of Human Vessels in Organ CultureJulia Serna PerezPublicación: Myocardin-Dependent Kv1.5 Channel Expression Prevents Phenotypic Modulation of Human Vessels in Organ Culture. ATVB. December 2019, Vol 39, Issue 12. https://doi.org/10.1161/ATVBAHA.119.313492 "UGT1A1 Variants c.864+5G>T and c.996+2_996+5del of a Crigler-Najjar Patient Induce Aberrant Splicing in Minigene Assays"Lara Sanoguera MirallesTercera autora del artículo de título "UGT1A1 Variants c.864+5G>T and c.996+2_996+5del of a Crigler-Najjar Patient Induce Aberrant Splicing in Minigene Assays" publicado el 6 de marzo del año 2020 en la revista Frontiers in Genetics. PAPER REMODELING OF INTRACELLULAR Ca2+HOMEOSTASIS IN RAT HIPPOCAMPASL NEURONS AGED IN VITROMaría Elena Hernando PérezARTICULO/REVIEW: REMODELING OF INTRACELLULAR Ca2+HOMEOSTASIS IN RAT HIPPOCAMPASL NEURONS AGED IN VITRO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.24 FEBRUARY 2020 Brain Atrophy and the Risk of Futile Endovascular Reperfusion in Acute Ischemic StrokeMARIA ISABEL PEDRAZA HUESOHipoacusia bilateral como forma de presentación en la carcinomatosis meníngeaMARIA ISABEL PEDRAZA HUESOLymphocytopenia as a Predictor of Mortality in Patients with ICU-Acquired Pneumonia. J Clin Med.MARTA MARTIN FERNÁNDEZdoi: 10.3390/jcm8060843. Endothelial Dysfunction Is an Early Indicator of Sepsis and Neutrophil Degranulation of Septic Shock in Surgical Patients. BJS OpenMARTA MARTIN FERNÁNDEZDOI: 10.1002/bjs5.50265 Current gaps in sepsis immunology: new opportunities for translational research. Lancet Infectious DiseasesMARTA MARTIN FERNÁNDEZdoi: 10.1016/S1473-3099(19)30567-5 Composed endotypes to guide antibiotic discontinuation in sepsis. Crit. CareMARTA MARTIN FERNÁNDEZdoi: 10.1186/s13054-019-2439-0. MR- proADM to detect specific types of organ failure in infection. Eur J Clin Invest.MARTA MARTIN FERNÁNDEZdoi: 10.1111/eci.13246. Myocardin-Dependent Kv1.5 Channel Expression Prevents Phenotypic Modulation of Human Vessels in Organ CultureMARYCARMEN ARÉVALO MARTÍNEZLipid-Binding Proteins in Brain Health and DiseaseMIRIAM CORRALIZA GOMEZPublicación de la Revisión "Lipid-Binding Proteins in Brain Health and Disease" en la revista "Frontiers in Neurology" doi: 10.3389/fneur.2019.01152 The MTT-formazan assay: Complementary technical approaches and in vivo validation in Drosophila larvaeMIRIAM CORRALIZA GOMEZEste artículo fue publicado en enero de 2018, pero el curso pasado se me olvidó subirlo a mi Documento de Actividades. Lo incluyo ahora porque la convocatoria de becas de movilidad de la UVa de este año va a tener en cuenta como historial científico de los solicitantes su SIGMA-UVa. https://doi.org/10.1016/j.acthis.2018.01.006 Apolipoprotein D-mediated preservation of lysosomal function promotes cell survival and delays motor impairment in Niemann-Pick type A diseaseMIRIAM CORRALIZA GOMEZApolipoprotein D-mediated preservation of lysosomal function promotes cellsurvival and delays motor impairment in Niemann-Pick type A disease. Raquel Pascua-Maestro, Miriam Corraliza-Gomez, Cristian Fadrique-Rojo, Maria D. Ledesma,Edward H. Schuchman, Diego Sanchez, Maria D. Ganfornina Neurobiology of disease 144 (2020) https://doi.org/10.1016/j.nbd.2020.105046 Modulation of Glial Responses by Furanocembranolides: Leptolide Diminishes Microglial Inflammation in Vitro and Ameliorates Gliosis In Vivo in a Mouse Model of Obesity and Insulin ResistanceMIRIAM CORRALIZA GOMEZModulation of Glial Responses by Furanocembranolides: Leptolide Diminishes Microglial Inflammation in Vitro and Ameliorates Gliosis In Vivo in a Mouse Model of Obesity and Insulin Resistance Marine Drugs, 22 July 2020 DOI: 10.3390/md18080378 Ischemia-reperfusion injury to coronary arteries: comprehensive microscopic study after reperfused myocardial infarction (en proceso de publicación)Nuria Daghbouche RubioPUBLICACIÓN REVIEW "The role of calcium signaling in Aging and Neurodegeneration: Insights fro Caenorhabditis elegant Models.PALOMA GARCÍA CASASAlvarez J, Alvarez-Illera P, García-Casas P, Fonteriz RI, Montero M. The Role of Ca2+ Signaling in Aging and Neurodegeneration: Insights from Caenorhabditis elegans models. Cells, 2020. 9(1) pii E204. Publicación ATVBSara Moreno EstarABSTRACT: SPATIOTEMPORAL INTRATUMOR GENETIC HETEROGENEITY AND CLONAL EVOLUTION IN PTCS AND PAIRED DM. ANNALS OF ONCOLOGY.Sara Gil BernabéSpatiotemporal intratumor genetic heterogeneity and clonal evolution in PTCs and paired DM Tipo de comunicación: Poster Discussion Publicación en: ESMO 2019 Abstract Book, (Supplement) Revista: Annals of Oncology DOI: https://doi.org/10.1093/annonc/mdz267.002 https://academic.oup.com/annonc/article/30/Supplement_5/mdz267.0 02/5578209 IF- 2018- JCR: 14.196 Publicación Acta BiomaterialiaSara Moreno EstarElastin-like recombinamer-based devices releasing Kv1.3 blockers for the prevention of intimal hyperplasia: An in vitro and in vivo study.SOFIA SERRANO DUCARA double safety lock tumor-specific device for suicide gene therapy in breast cancerSOFIA SERRANO DUCARGenetically engineered elastin-like recombinamers with sequence-based molecular stabilization as advanced bioinks for 3D bioprintingSORAYA SALINAS FERNÁNDEZAcceso al artículo científico (open access): https://www.sciencedirect.com/science/article/pii/S2352940719306195 2018/2019Caffeine chelates calcium in the lumen of the endoplasmic reticulumALBA DEL RÍO LORENZOAlternative splicing and ACMG-AMP-2015-based classification of PALB2 genetic variants: an ENIGMA report.ALBERTO VALENZUELA PALOMOJournal of Medical Genetics Mis-splicing in breast cancer: identification of pathogenic BRCA2 variants by systematic minigene assays.ALBERTO VALENZUELA PALOMOThe Journal of Pathology Publicación artículo: "Unraveling the molecular effect of a rare missense mutation in BRIP1 assiciated with inherited breast cancer"CAROLINA VELÁZQUEZ PÉREZTricarboxylic Acid Cycle Activity and Remodeling of Glycerophosphocholine Lipids Support Cytokine Induction in Response to Fungal Patterns.Cristina Mancebo TejeraTricarboxylic Acid Cycle Activity and Remodeling of Glycerophosphocholine Lipids Support Cytokine Induction in Response to Fungal Patterns. Cell Reports Encefalopatía inducida por metronidazol: descripción de un caso con hallazgos radiológicos y anatomopatológicosELENA MARTINEZ VELASCOEncefalopatía inducida por metronidazol: descripción de un caso con hallazgos radiológicos y anatomopatológicosELENA MARTINEZ VELASCOStore-operated Ca2+ entry and Ca2+ responses to hypothalamic releasing hormones in anterior pituitary cells from Orai1-/- and heptaTRPC knockout mice. Núñez L, Bird GS, Hernando-Pérez E, Pérez-Riesgo E, Putney JW Jr, Villalobos C.ENRIQUE PÉREZ RIESGOPublication in Biomedical Materials (IOP Science)Filippo CiprianiBicyclic RGD peptides with high integrin αvβ3 and α5β1 affinity promote cell adhesion on elastin-like recombinamers https://iopscience.iop.org/article/10.1088/1748-605X/aafd83 Publicacion en Biomacromolecules (ACS Journal)Filippo Ciprianihttps://pubs.acs.org/doi/10.1021/acs.biomac.8b01211 Publication in Regenerative Biomaterials (Oxford Academic)Filippo CiprianiAn elastin-like recombinamer-based bioactive hydrogel embedded with mesenchymal stromal cells as an injectable scaffold for osteochondral repair. https://academic.oup.com/rb/advance-article/doi/10.1093/rb/rbz023/5492343 Publicación de artículo: Lipopolysaccharide and interferon-γ team up to activate HIF-1 via STAT1 in normoxia and exhibit sex differences in human aortic valve interstitial cells.IRENE CASTAÑOS-MOLLOR MORCILLOLipopolysaccharide and interferon-γ team up to activate HIF-1 via STAT1 in normoxia and exhibit sex differences in human aortic valve interstitial cells. Iván Parra-Izquierdo, Irene Castaños-Mollor, Javier López,Cristina Gómez, J Alberto San Román, Mariano Sánchez Crespo, Carmen García-Rodríguez DOI: 10.1016/j.bbadis.2019.04.014 Publicación de un artículo de InvestigaciónIVÁN PARRA IZQUIERDOArtículo original de investigación: Lipopolysaccharide and interferon-γ team up to activate HIF-1; via STAT1 in normoxia and exhibit sex differences in human aortic valve interstitial cells. Parra-Izquierdo I, Castaños-Mollor I, López J, Gómez C, San Román JA, Sánchez Crespo M, García-Rodríguez C. Biochim Biophys Acta Mol Basis Dis. 2019 Apr 26. cell reportsJose Javier Fernandez RodriguezTricarboxylic Acid Cycle Activity and Remodeling of Glycerophosphocholine Lipids Support Cytokine Induction in Response to Fungal Patterns Vázquez, P., Hernández-Sánchez, C., Escalona-Garrido, C., Pereira, L., Contreras, C., López, M., Balsinde, J., de Pablo, F. & Valverde, Á.M. (2018) Increased FGF21 in brown adipose tissue of tyrosine hydroxylase heterozygous mice: implications for cold adaptation. J Lipid Res 59(12):2308-2320LAURA PEREIRA DE BLASVázquez, P., Hernández-Sánchez, C., Escalona-Garrido, C., Pereira, L., Contreras, C., López, M., Balsinde, J., de Pablo, F. & Valverde, Á.M. (2018) Increased FGF21 in brown adipose tissue of tyrosine hydroxylase heterozygous mice: implications for cold adaptation. J Lipid Res 59(12):2308-2320 Guijas, C., Bermúdez, M.A., Meana, C., Astudillo, A.M., Pereira, L., Fernández-Caballero, L., Balboa, M.A. & Balsinde J. (2019) Neutral lipids are not a source of arachidonic acid for lipid mediator signaling in human foamy monocytes. Cells 8: 941LAURA PEREIRA DE BLASGuijas, C., Bermúdez, M.A., Meana, C., Astudillo, A.M., Pereira, L., Fernández-Caballero, L., Balboa, M.A. & Balsinde J. (2019) Neutral lipids are not a source of arachidonic acid for lipid mediator signaling in human foamy monocytes. Cells 8: 941. Activation of the cation channel TRPM3 in perivascular nerves induces vasodilation of resistance arteriesLUCÍA ALONSO CARBAJO"TRPC1 and Orai1 channels in colon cancer"LUCÍA GONZÁLEZ GUTIÉRREZArtículo de Investigación: Villalobos C1, Hernández-Morales M2, Gutiérrez LG3, Núñez L3. TRPC1 and ORAI1 channels in colon cancer. Cell Calcium. 2019 Jul;81:59-66. Inhibition of polyamine biosynthesis reverses Ca2+ channel remodeling in colon cancer cellsLUCÍA GONZÁLEZ GUTIÉRREZPublicación en Cancers Journal Q1; https://www.mdpi.com/2072-6694/11/1/83 "Mitochondrial control... in cancer: Pharmacological implications"LUCÍA GONZÁLEZ GUTIÉRREZArtículo de investigación en la revista "Pharmacological Research" Villalobos C1, Gutiérrez LG2, Hernández-Morales M3, Del Bosque D2, Núñez L4.Mitochondrial control of store-operated Ca2+ channels in cancer: Pharmacological implications.Pharmacol Res. 2018 Sep;135:136-143 Lucía Núñez, Gary S. Bird, Elena Hernando-Pérez, Enrique Pérez-Riesgo, James W. Putney, Carlos Villalobos, Store-operated Ca2+ entry and Ca2+ responses to hypothalamic releasing hormones in anterior pituitary cells from Orai1−/− and heptaTRPC knockout mice, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1866, Issue 7, 2019, Pages 1124-1136, ISSN 0167-4889, https://doi.org/10.1016/j.bbamcr.2018.11.006.María Elena Hernando PérezCalvo-Rodriguez, M., Hernando-Perez, E., Nuñez, L., & Villalobos, C. (2019). Amyloid β Oligomers Increase ER-Mitochondria Ca2+ Cross Talk in Young Hippocampal Neurons and Exacerbate Aging-Induced Intracellular Ca2+ Remodeling. Frontiers in cellular neuroscience, 13, 22. doi:10.3389/fncel.2019.00022María Elena Hernando PérezCefalea: embarazo y lactancia. Recomendaciones del Grupo de Estudio de Cefaleas de la Sociedad Española de Neurología (GECSEN)MARINA RUIZ PIÑEROcoautora Congestión nasal como síntoma autonómico acompañante de crisis migrañosasMARINA RUIZ PIÑEROcoautor "Shared Features of Endothelial Dysfunction between Sepsis and Its Preceding Risk Factors (Aging and Chronic Disease)". Journal of Clinical MedicineMARTA MARTIN FERNÁNDEZArtículo como co-primera autora en la revista Scientific Reports, de 1º decil Impact of Lymphocyte and Neutrophil Counts on Mortality Risk in Severe Community-Acquired Pneumonia with or without Septic Shock. J. Clin. Med. 2019, 8, 754; doi:10.3390/jcm8050754MARTA MARTIN FERNÁNDEZGuijas, C., Bermúdez, M.A., Meana, C., Astudillo, A.M., Pereira, L., Fernández-Caballero, L., Balboa, M.A. & Balsinde J. (2019) Neutral lipids are not a source of arachidonic acid for lipid mediator signaling in human foamy monocytes. Cells 8: 941MIGUEL ANGEL BERMUDEZ ARIASCoautor del siguiente trabajo científico: Guijas, C., Bermúdez, M.A., Meana, C., Astudillo, A.M., Pereira, L., Fernández-Caballero, L., Balboa, M.A. & Balsinde J. (2019) Neutral lipids are not a source of arachidonic acid for lipid mediator signaling in human foamy monocytes. Cells 8: 941 The role of lipins in innate immunity and inflammation. Balboa MA, de Pablo N, Meana C, Balsinde J. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids Volume 1864, Issue 10, October 2019, Pages 1328-1337NAGORE DE PABLO HERRANZPUBLICACIÓN EN FRONTIERS AGING NEUROSCIENCEPALOMA GARCÍA CASASPUBLICACIÓN DEL SEGUNDO ARTÍCULO DERIVADO DE LOS RESULTADOS DE LA TESIS DOCTORAL. Lebrero, P., Astudillo, A.M., Rubio, J.M., Fernández-Caballero, L., Kokotos, G., Balboa, M.A. & Balsinde, J. (2019) Cellular plasmalogen content does not influence arachidonic acid levels or distribution in macrophages: a role for cytosolic phospholipase A2γ in phospholipid remodeling.PATRICIA LEBRERO FERNÁNDEZTricarboxylic Acid Cycle Activity and Remodeling of Glycerophosphocholine Lipids Support Cytokine Induction in Response to Fungal PatternsSaioa Márquez PiñeiroABSTRACT: Spatio-temporal genetic heterogeneity and clonal evolution in advanced papillary thyroid carcinomas and matched distant metastases. Revista: Cancer Research 2019; 79(13 Suppl).Sara Gil BernabéAutores: Sara Gil-Bernabé, Noa Feas Rodríguez, Miriam Vega Herrero, Jose Javier Estébanez García, Ginesa M. Garcia-Rostan. Título: Spatio-temporal genetic heterogeneity and cAbstract reference: 2770. Revista: Cancer Res 2019; 79(13 Suppl). DOI: 10.1158/1538-7445.SABCS18-2770 Fecha: Julio 2019 http://cancerres.aacrjournals.org/content/79/13_Supplement/2770 IF- 2018- JCR: 8.378 Publicacion en Revista cientifica. Elsevier. "Comparative analysis study of two assays for anti-DFS70 antibodies determination"SOFIA AMELIA PEREZ ZARAGOZAPublicacion en Revista cientifica. Elsevier. "Comparative analysis study of two assays for anti-DFS70 antibodies determination" Autores:A. Esteban, B. Aparicio, S. Lorenzo, S. Perez Zaragoza, P. Garcia Fernandez-Rufete, L. Llorca. doi:10.1016/j.cca.2019.03.198 Presentado en EuroMedLab 2019 como miembro de la Comisión de Bioquímica de Enfermedades Inmunológicas de la SEQC. Tethering QK peptide to enhance angiogenesis in elastin-like recombinamer (ELR) hydrogelsTatjana FloraUse of proteolytic sequences with different cleavage kinetics as a way to generate hydrogels with preprogrammed cell-infiltration patterns imparted over their given 3D spatial structureTatjana Flora2017/2018Molecular Cell. Systematic Identification of MCU Modulators by Orthogonal Interspecies Chemical ScreeningALBA DEL RÍO LORENZOIdentification of Eight Spliceogenic Variants in BRCA2 Exon 16 by Minigene Assays.ALBERTO VALENZUELA PALOMOFunctional Analyses of a Novel Splice Variant in the CHD7 Gene, Found by Next Generation Sequencing, Confirm Its Pathogenicity in a Spanish Patient and Diagnose Him with CHARGE Syndrome.ALBERTO VALENZUELA PALOMOGenetic dissection of the BRCA2 promoter and transcriptional impact of DNA variants.ALBERTO VALENZUELA PALOMOIdentification of Eight Spliceogenic Variants in BRCA2 Exon 16 by Minigene Assays.ALBERTO VALENZUELA PALOMOPapel de las formas inmaduras en SepsisCRISTINA ANDRES LEDESMACombined quantification of procalcitonin and HLA-DR improves sepsis detection in surgical patients COMBINED QUANTIFICATION OF PROCALCITONIN AND HLA-DR IMPROVES SEPSIS DETECTION IN SURGICAL PATIENTSCRISTINA ANDRES LEDESMACOMBINED QUANTIFICATION OF PROCALCITONIN AND HLA-DR IMPROVES SEPSIS DETECTION IN SURGICAL PATIENTS QUANTIFICATION OF IMMUNE DYSREGULATION BY NEXT-GENERATION POLYMERASE CHAIN REACTION TO IMPROVE SEPSIS DIAGNOSIS IN SURGICAL PATIENTSCRISTINA ANDRES LEDESMAQUANTIFICATION OF IMMUNE DYSREGULATION BY NEXT-GENERATION POLYMERASE CHAIN REACTION TO IMPROVE SEPSIS DIAGNOSIS IN SURGICAL PATIENTS. Ann Surg. 2017 Jul 7. Factor de impacto: 8,980. EL PARADIGMA DE LA SEPSIS: EN BUSCA DEL BIOMARCADOR PERFECTOCRISTINA ANDRES LEDESMAEditorial en la Revista del Laboratorio Clínico Insulin degrading enzyme is up-regulated in pancreatic β cells by insulin treatment. Revista: Histol. and Hispopathology Fecha: May 2018Cristina María Fernández Díazhttps://www.ncbi.nlm.nih.gov/pubmed/29726577 "Protective effects of epoxypukalide on pancreatic beta‐cells and glucose metabolism in STZinduced diabetic mice" Revista: Islets. Fecha: Mar 2015Cristina María Fernández Díazhttps://www.ncbi.nlm.nih.gov/pubmed/26406478 Elastin-like materials for tissue regeneration and repairFilippo CiprianiELASTIN-LIKE POLYMERS: PROPERTIES, SYNTHESIS AND APPLICATIONSFilippo CiprianiArtículo: "Calcification Induced by Type I Interferon in Human Aortic Valve Interstitial Cells Is Larger in Males and Blunted by a Janus Kinase Inhibitor"IRENE CASTAÑOS-MOLLOR MORCILLO"Calcification Induced by Type I Interferon in Human Aortic Valve Interstitial Cells Is Larger in Males and Blunted by a Janus Kinase Inhibitor" Iván Parra-Izquierdo , Irene Castaños-Mollor , Javier López , Cristina Gómez , J. Alberto San Román , Mariano Sánchez Crespo and Carmen García-Rodríguez 2018;0:ATVBAHA.118.311504 MINI REVIEW ARTICLEIRENE CASTAÑOS-MOLLOR MORCILLOMINI REVIEW ARTICLE Front. Physiol., 12 March 2018 | https://doi.org/10.3389/fphys.2018.00201 "Toll-Like Receptors, Inflammation, and Calcific Aortic Valve Disease" Carmen García-Rodríguez, Iván Parra-Izquierdo, Irene Castaños-Mollor, Javier López, J. Alberto San Román and Mariano Sánchez Crespo The role of oxidative stress in the crosstalk between leptin and mineralocorticoid receptor in the cardiac fibrosis associated with obesity. Gutiérrez-Tenorio J, Marín-Royo G, Martínez-Martínez E, Martín R, Miana M, López-Andrés N, Jurado-López R, Gallardo I, Luaces M, San Román JA, González-Amor M, Salaices M, Nieto ML, Cachofeiro V. Sci Rep. 2017 Dec 1;7(1):16802. doi: 10.1038/s41598-017-17103-9.ISABEL GALLARDO ROMEROInhibition of galectin-3 ameliorates the consequences of cardiac lipotoxicity in a rat model of diet-induced obesity. Gema Marín-Royo,1,* Isabel Gallardo,2,* Ernesto Martínez-Martínez,1 Beatriz Gutiérrez,2 Raquel Jurado-López,1 Natalia López-Andrés,3 Josué Gutiérrez-Tenorio,1 Eduardo Rial,4 María Visitación Bartolomé,5,6 María Luisa Nieto,2,6, and Victoria Cachofeiro1,6,§ISABEL GALLARDO ROMEROPublicación de un articulo original de InvestigaciónIVÁN PARRA IZQUIERDOhttps://www.ncbi.nlm.nih.gov/pubmed/30026273 Publicación de una mini-revisión en Frontiers in PhysiologyIVÁN PARRA IZQUIERDOTítulo: Toll-Like Receptors, Inflammation,and Calcific Aortic Valve Disease Artículo de InvestigaciónJESICA ARIAS DEL VALInhibition of Sarco-Endoplasmic Reticulum Ca2+ ATPase Extends the Lifespan in C. elegans Worms Front Immunol. 2017 Jun 19;8:639. doi: 10.3389/fimmu.2017.00639. eCollection 2017.Jose Javier Fernandez RodriguezFront Immunol. 2017 Jun 19;8:639. doi: 10.3389/fimmu.2017.00639. eCollection 2017. Endoplasmic Reticulum Stress Sensor IRE1α Enhances IL-23 Expression by Human Dendritic Cells. Márquez S1, Fernández JJ1, Terán-Cabanillas E2,3,4, Herrero C5, Alonso S5, Azogil A5, Montero O6, Iwawaki T7, Cubillos-Ruiz JR2,3, Fernández N1,5, Crespo MS5. Astudillo, A. M., Meana, C., Guijas, C., Pereira, L., Lebrero, P., Balboa, M. A. & Balsinde, J. (2018) Occurrence and biological activity of palmitoleic acid isomers in phagocytic cells. J. Lipid Res 59: 237-249.LAURA PEREIRA DE BLASAstudillo, A. M., Meana, C., Guijas, C., Pereira, L., Lebrero, P., Balboa, M. A. & Balsinde, J. Occurrence and biological activity of palmitoleic acid isomers in phagocytic cells.LAURA PEREIRA DE BLASCoautor en Cápitulo: 4 Elastin-like proteins: Molecular design for self-assemblingMARCOS HERRERO GUTIERREZhttps://doi.org/10.1016/B978-0-08-102015-9.00004-6 Pages 4978 Chapter: 4 Elastin-like proteins: Molecular design for self-assembling Book: Self-assembling Biomaterials Author: Jose C. Rodríguez-Cabello,Israel González de Torre,Sergio Acosta,Soraya Salinas,Marcos Herrero Publisher: Elsevier Date: 2018 Artículo "Tuning the Stiffness of Surfaces by Assembling Genetically Engineered Polypeptides with Tailored Amino Acid Sequence"MARCOS HERRERO GUTIERREZArtículo publicado en la revista Biomacromolecules. DOI: 10.1021/acs.biomac.8b00723 Identification of Eight Spliceogenic Variants in BRCA2 Exon 16 by Minigenes Assays.MARIA EUGENIA FRAILE BETHENCOURTFraile-Bethencourt E., Valenzuela-Palomo A., Díez-Gómez B., Acedo A. & Velasco EA. Frontiers in Genetics 2018. Identification of Eight Spliceogenic Variants in BRCA2 Exon 16 by Minigenes Assays. Doi: 10.3389/fgene.2018.00188 Characterization of spliceogenic variants located in regions linked to high levels of alternative splicing: BRCA2 c.7976+5G > T as a case study.MARIA EUGENIA FRAILE BETHENCOURTMontalban, G., Fraile-Bethencourt, E., López-Perolio, I., Pérez-Segura, P., Infante, M., Durán, M., et al. (2018). Characterization of spliceogenic variants located in regions linked to high levels of alternative splicing: BRCA2 c.7976+5G > T as a case study. Hum. Mutat., 16. doi:10.1002/humu.23583. Genetic dissection of the BRCA2 promoter and transcriptional impact of DNA variantsMARIA EUGENIA FRAILE BETHENCOURTFraile-Bethencourt E, Valenzuela-Palomo A, Díez-Gómez B, Infante M, Durán M, Marcos G, Lastra E, Gómez-Barrero S & Velasco EA (2018) Genetic dissection of the BRCA2 promoter and transcriptional impact of DNA variants. Breast Cancer Research and Treatment. Available at: https://doi.org/10.1007/s10549-018-4826-7 Role of reactive oxygen species and sulfide-quinone oxoreductase in hydrogen sulfide-induced contraction of rat pulmonary arteries.MARÍA INMACULADA DOCIO CUADRADORole of reactive oxygen species and sulfide-quinone oxoreductase in hydrogen sulfide-induced contraction of rat pulmonary arteries. Prieto-Lloret J, Snetkov VA, Shaifta Y, Docio I, Connolly MJ, MacKay CE, Knock GA, Ward JPT, Aaronson PI. Am J Physiol Lung Cell Mol Physiol. 2018 Apr 1;314(4):L670-L685. doi: 10.1152/ajplung.00283.2016. Epub 2017 Dec 28. Guinea Pig as a model to study the carotid body mediated chronic intermittent hypoxia effects.MARÍA INMACULADA DOCIO CUADRADOGuinea Pig as a model to study the carotid body mediated chronic intermittent hypoxia effects. Inmaculada Docio, Elena Olea, Jesus Prieto-Lloret, Teresa Gallego, Ana Obeso, Angela Gomez-Niño, Asunción Rocher. Front. Physiol. 9:694. doi: 10.3389/fphys.2018.00694 Mitochondrial Complex I dysfunction and peripheral chemoreflex sensitivity in a FASTK-deficient mice model.MARÍA INMACULADA DOCIO CUADRADOMitochondrial Complex I dysfunction and peripheral chemoreflex sensitivity in a FASTK-deficient mice model. Angela Gomez-Niño, Inmaculada Docio, Jesus Prieto-Lloret, Maria Simarro, Miguel A. de la Fuente, Asuncion Rocher. Adv Exp Med Biol (in press). Nasal congestion as an autonomic symptom accompanying migraine attacks. de Lera M, Lopez-Mesonero L, Pedraza MI, Martinez-Velasco E, Ruiz-Pinero M, Guerrero-Peral AL. Rev Neurol. 2018 Sep 1;67(5):193-19MARIA ISABEL PEDRAZA HUESODistributed rhythm generators underlie Caenorhabditis elegans forward locomotionMARIA PILAR ALVAREZ ILLERACómo y cuándo derivar un paciente con cefalea primaria y neuralgia craneofacial desde Urgencias y Atención Primaria: recomendaciones del Grupo de Estudio de Cefalea de la Sociedad Espanola de NeurologíaMARINA RUIZ PIÑEROEffect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data.MARINA RUIZ PIÑEROAutor colaborador. Pre-sepsis: A necessary concept to complete the SEPSIS-3 picture' Journal of Critical CareMARTA MARTIN FERNÁNDEZPublicado en Journal of Critical Care "Combined quantification of procalcitonin and HLA-DR improves sepsis detection in surgical patients". Scientific ReportsMARTA MARTIN FERNÁNDEZArtículo como co-primera autora en la revista Scientific Reports, de 1º cuartil. Immunological profiling to assess disease severity and prognosis in community-acquired pneumonia. Lancet Respiratory MedicineMARTA MARTIN FERNÁNDEZPublicado en Lancet Respiratory Medicine Quantification of Immune Dysregulation by Next-generation Polymerase Chain Reaction to Improve Sepsis Diagnosis in Surgical Patients. Annals of Surgery.MARTA MARTIN FERNÁNDEZArtículo publicado en Annals of Surgery Lipin-2 regulates NLRP3 inflammasome by affecting P2X7 receptor activationMIREN ITZIAR SANJUAN GARCIAGema Lordén,1,3 Itziar Sanjuán-García,1,3 Nagore de Pablo,1,3 Clara Meana,1,3 Inés Alvarez-Miguel,1,2 M. Teresa Pérez-García,1,2 Pablo Pelegrín,4 Jesús Balsinde,1,3 and María A. Balboa1,3 Cembranoids from Eunicea sp. enhance insulin-producing cells proliferationNAGORE DE PABLO HERRANZPUBLICACIÓN PAPER TESISPALOMA GARCÍA CASAS"Inhibition of Sarco-Endoplasmic Reticulum Ca2+ ATPase Extends the lifespan in C. Elegans worms" García-Casas P, Arias-del-Vañ J, Alvarez Illera I, Fonteriz R, Montero M y Alvarez J. Astudillo, A. M., Meana, C., Guijas, C., Pereira, L., Lebrero, P., Balboa, M. A. & Balsinde, J. (2017) "Occurrence and Biological Activity of Palmitoleic Acid Isomers in Phagocytic Cells". J. Lipid Res. doi: 10.1194/jlr.M079145PATRICIA LEBRERO FERNÁNDEZGil-de-Gómez, L., Astudillo, A. M., Lebrero, P., Balboa, M. A. & Balsinde, J. (2017) Essential role for ethanolamine plasmalogen hydrolysis in bacterial lipopolysaccharide priming of macrophages for enhanced arachidonic acid release. Front. Immunol. 8:1251.PATRICIA LEBRERO FERNÁNDEZMyelin extracellular leaflet compaction requires apolipoprotein D membrane management to optimize lysosomal-dependent recycling and glycocalyx removal.RAQUEL PASCUA MAESTROMyelin extracellular leaflet compaction requires apolipoprotein D membrane management to optimize lysosomal-dependent recycling and glycocalyx removal. García-Mateo N, Pascua-Maestro R, Pérez-Castellanos A, Lillo C, Sanchez D, Ganfornina MD. Glia. 2018 Mar;66(3):670-687. doi: 10.1002/glia.23274. Epub 2017 Dec 9. Entrevista en la MatacaraRAQUEL PASCUA MAESTROSe trata de una revista de divulgación The MTT-formazan assay: Complementary technical approaches and in vivo validation in Drosophila larvae. (Corresponding author).RAQUEL PASCUA MAESTROThe MTT-formazan assay: Complementary technical approaches and in vivo validation in Drosophila larvae. Drosophila larvae. Pascua-Maestro R, Corraliza-Gomez M, Diez-Hermano S, Perez-Segurado C, Ganfornina MD, Sanchez D. Acta Histochem. 2018 Apr;120(3):179-186. doi: 10.1016/j.acthis.2018.01.006. Epub 2018 Feb 1. Biomedical Applications of Recombinant Proteins and Derived PolypeptidesSergio Acosta RodríguezBiomedical Applications of Recombinant Proteins and Derived Polypeptides F. J. Arias, S. Acosta-Rodríguez, T. Flora, S. Serrano-Dúcar 2017 Chapter 8 of the book entitled Biopolymers for Medical Applications, edited by J. M. Ruso and P. Messina, CRC Press/Taylor & Francis Group. https://www.taylorfrancis.com/books/e/9781498744973/chapters/10.1201%2F9781315368863-13 Elastin like recombinamers, a modular design to form nanoparticles and hydrogels for medical applicationsSergio Acosta RodríguezElastin like recombinamers, a modular design to form nanoparticles and hydrogels for medical applications J. C. Rodríguez Cabello, S. Acosta-Rodríguez, M. González, I. González de Torre, M. Alonso In press Chapter of the book entitled Self-Assembling Biomaterials: Molecular Design, Characterization and Application in Biology and Medicine, Elsevier. Elastin-like Proteins - Modular Design for Self-AssemblingSergio Acosta RodríguezElastin like Proteins Molecular Design for Self-Assembling J. C. Rodríguez Cabello, I. González de Torre, S. Acosta, S. Salinas, M. Herrero Chapter 4 of the book Self-assembling Biomaterials. 2018, Pages 4978 https://www.sciencedirect.com/science/article/pii/B9780081020159000046 Tipo de producción: Artículo Tipo de soporte: Revista Genetically Engineered Elastin-based Biomaterials for Biomedical Applications Francisco Javier Arias, Mercedes Santos, Sofía Serrano-Dúcar, Juan Gonzalez-Valdivieso, Reinaldo Vallejo, Alessandra Girotti y Purificación Cuadrado. (E-pub Ahead of Print). (https://doi.org/10.2174/0929867325666180508094637).SOFIA SERRANO DUCARJ.C. Rodríguez-Cabello, I. González de Torre, S. Acosta, S. Salinas-Fernández, M. Herrero. Elastin like Proteins molecular design for self-assembling. In Self-Assembling Biomaterials, Molecular Design, Characterization and Application in Biology and Medicine. Woodhead Publishing, 2018. doi: 10.1016/B978-0-08-102015-9.00004-6SORAYA SALINAS FERNÁNDEZSpatial control and cell adhesion selectivity on model gold surfaces grafted with elastin-like recombinamersTatjana Flora2016/2017PAPER EN PROCESO DE SER ACEPTADOALBERTO VALENZUELA PALOMOFörster Resonance Energy Transfer-Paired Hydrogel Forming Silk-Elastin-Like Recombinamers by Recombinant Conjugation of Fluorescent ProteinsARTURO IBAÑEZ FONSECARevista: Bioconjugate Chemistry. DOI: 10.1021/acs.bioconjchem.6b00738 Bone regeneration mediated by a bioactive and biodegradable ECM-like hydrogel based on elastin-like recombinamersARTURO IBAÑEZ FONSECARevista: Tissue Engineering Part A. DOI: 10.1089/ten.TEA.2017.0047 Elastin-like Polymers: Properties, Synthesis and ApplicationsARTURO IBAÑEZ FONSECARevista: Encyclopedia of Polymer Science and Technology. DOI: 10.1002/0471440264.pst656 Regeneration of hyaline cartilage promoted by xenogeneic mesenchymal stromal cells embedded within elastin-like recombinamer-based bioactive hydrogelsARTURO IBAÑEZ FONSECARevista: Journal of Materials Science: Materials in Medicine. DOI: 10.1007/s10856-017-5928-1 Biocompatibility of two model elastin-like recombinamer-based hydrogels formed through physical or chemical crosslinking for various applications in tARTURO IBAÑEZ FONSECARevista: Journal of Tissue Engineering and Regenerative Medicine A dangerous liaison: Leptin and sPLA2-IIA join forces to induce proliferation and migration of astrocytoma cells Rubén Martín, Claudia Cordova, BeaBEATRIZ ROSA GUTIERREZ MIRANDAhttps://doi.org/10.1371/journal.pone.0170675 Netrin¿1 and multiple sclerosis: a new biomarker for neuroinflammation' P Mulero, C Córdova, M Hernández, R Martín, B Gutiérrez, JC Muñoz, N Redondo,BEATRIZ ROSA GUTIERREZ MIRANDADOI: 10.1111/ene.13340 "The impact of obesity in the cardiac lipidomic and its consequences in the cardiac damage observed in obese rats." Marín-Royo G, Martínez-Martínez E,BEATRIZ ROSA GUTIERREZ MIRANDAClin Investig Arterioscler. 2017 Aug 28. pii: S0214-9168(17)30090-6. doi: 10.1016/j.arteri.2017.07.004. Relation between serum levels of chemotaxis-related factors and the presence of coronary artery calcification as expression of subclinical atherosclerBEATRIZ ROSA GUTIERREZ MIRANDAhttps://doi.org/10.1016/j.clinbiochem.2017.08.012 Superior accuracy of mid-regional proadrenomedullin for mortality prediction in sepsis with varying levels of illness severity.CRISTINA ANDRES LEDESMALa ProADM (proadrenomedulina) es un biomarcador que ha demostrado en los últimos años una gran utilidad como predictor de la mortalidad en Sepsis. Características clínicas de la migraña vestibular: consideraciones en una serie de 41 pacientesELENA MARTINEZ VELASCOTranscriptomic Analysis of Calcium Remodeling in Colorectal CancerENRIQUE PÉREZ RIESGOÁlvarez-Miguel I et al. Mar 2017. "Differences in TRPC3 and TRPC6 channels assembly in mesenteric vascular smooth muscle cells in essential hypertensiINÉS ÁLVAREZ MIGUELLordén G et al. Feb 2017. "Lipin-2 regulates NLRP3 inflammasome by affecting P2X7 receptor activation". The Journal of Experimental Medicine. 214(2):5INÉS ÁLVAREZ MIGUELNetrin-1 and multiple sclerosis: a new biomarker for neuroinflammation'P. Mulero,C. Córdova,M. Hernández, R. Martín,B. Gutiérrez,J. C. Muñoz,N. RedonISABEL GALLARDO ROMEROThe impact of obesity in the cardiac lipidomic and its consequences in the cardiac damage observed in obese rats. 2017 Aug 28. pii: S0214-9168(17)3009ISABEL GALLARDO ROMEROMarín-Royo G, Martínez-Martínez E, Gutiérrez B, Jurado-López R, Gallardo I, Montero O, Bartolomé MV, Román JAS, Salaices M, Nieto ML, Cachofeiro V. Functional roles of MICU1 and MICU2 in mitochondrial Ca(2+) uptake.JESICA ARIAS DEL VALMatesanz-Isabel J, Arias-del-Val J, Alvarez-Illera P, Fonteriz RI, Montero M, Alvarez J. Biochim Biophys Acta. 2016 Jun;1858(6):1110-7. Modulation of Calcium Entry by MitochondriaJESICA ARIAS DEL VALFonteriz R, Matesanz-Isabel J, Arias-Del-Val J, Alvarez-Illera P, Montero M, Alvarez J. Adv Exp Med Biol. 2016;898:405-21. "Pharynx mitochondrial [Ca2+] dynamics in live C.elegans worms during aging"JESICA ARIAS DEL VALPilar Alvarez-Illera, Paloma García-Casas, Jessica Arias-del-Val, Rosalba I.Fonteriz, Javier Alvarez and Mayte Montero; Oncotarget June 22, 2017 Muscling in on TRP channels in vascular smooth muscle cells and cardiomyocytes.LUCÍA ALONSO CARBAJOCell Calcium. 2017 Sep;66:48-61. doi: 10.1016/j.ceca.2017.06.004. Epub 2017 Jun 15. María Teresa Alonso, Macarena Rodríguez-Prados, Paloma Pavas-Navarro, Jonathan Rojo-Ruiz, Javier García-Sancho. Using aequorin probes to measure Ca2+MACARENA RODRIGUEZ VALLEUsing aequorin probes to measure Ca2+ in intracellular organelles María Teresa Alonso, Jonathan Rojo-Ruiz, Paloma Navas-Navarro, Macarena Rodríguez-Prados, Javier García-Sancho. Measuring Ca2+ inside intracellular oMACARENA RODRIGUEZ VALLEMeasuring Ca2+ inside intracellular organelles with luminescent and fluorescent aequorin-based sensors Genetic dissection of the BRCA2 promoter and transcriptional impact of DNA variantsMARIA EUGENIA FRAILE BETHENCOURTArticulo sometido, en vías de aceptación. Functional classification of DNA variants by hybrid minigenes: Identification of 30 spliceogenic variants of BRCA2 exons 17 and 18.MARIA EUGENIA FRAILE BETHENCOURTPLoS Genet. 2017 Mar 24;13(3):e1006691. doi: 10.1371/journal.pgen.1006691. eCollection 2017. Guinea Pig Oxygen-Sensing and Carotid Body Functional Properties Gonzalez-Obeso E, Docio I, Olea E, Cogolludo A, Obeso A, Rocher A, Gomez-Niño AMARÍA INMACULADA DOCIO CUADRADOFront Physiol. 2017 May 8;8:285. doi: 10.3389/fphys.2017.00285. eCollection 2017. American Thoracic Society InternationalMARÍA INMACULADA DOCIO CUADRADOHeadache in young patients: Clinical characteristics of a series of 651 cases. Neurologia. 2017 Jan 10MARIA ISABEL PEDRAZA HUESOFunctional roles of MICU1 and MICU2 in mitochondrial Ca(2+) uptake. Matesanz-Isabel J, Arias-del-Val J, Alvarez-Illera P, Fonteriz RI, Montero M, AlvMARIA PILAR ALVAREZ ILLERAPharynx mitochondrial [Ca2+] dynamics in live C. elegans worms during aging. Alvarez-Illera P1, García-Casas P1, Arias-Del-Val J1, Fonteriz RI1, AlMARIA PILAR ALVAREZ ILLERAModulation of Calcium Entry by Mitochondria. Fonteriz R, Matesanz-Isabel J, Arias-Del-Val J, Alvarez-Illera P, Montero M, Alvarez J. Adv Exp Med BioMARIA PILAR ALVAREZ ILLERALong-term monitoring of Ca2+ dynamics in C. elegans pharynx: an in vivo energy balance sensor. Alvarez-Illera P, Sanchez-Blanco A, Lopez-Burillo S, FMARIA PILAR ALVAREZ ILLERARoller pressure algometry as a new tool for assessing dynamic pressure sensitivity in migraineMARINA RUIZ PIÑERO"Characterizing Systemic Immune Dysfunction Syndrome to Fill in the Gaps of SEPSIS-2 and SEPSIS-3 Definitions". Chest. 2017 Feb;151(2):518-519. doi: 1MARTA MARTIN FERNÁNDEZ"In Vitro Aging Promotes Endoplasmic Reticulum (ER)-mitochondria Ca2+ Cross Talk and Loss of Store-Operated Ca2+ Entry (SOCE) in Rat Hippocampal NeuroMONICA GARCIA DURILLOAutores: Calvo-Rodríguez M, García-Durillo M, Villalobos C, Núñez L. "Aging enables Ca2+ overload and apoptosis induced by amyloid ß oligomers in rat hippocampal neurons: neuroprotection by non-steroidal anti-inflammatoMONICA GARCIA DURILLOAutores: Calvo-Rodríguez, M., M. García-Durillo, C. Villalobos and L. Núñez (2016). "Aging and amyloid ß oligomers enhance TLR4 expression, LPS-induced Ca2+ responses, and neuron cell death in cultured rat hippocampal neurons"MONICA GARCIA DURILLOAutores: Calvo-Rodríguez, M., C. de la Fuente, M. García-Durillo, C. García-Rodríguez, C. Villalobos and L. Núñez Lipin-2 regulates NLRP3 inflammasome by affecting P2X7 receptor activation. Lordén G, Sanjuán-García I, de Pablo N, Meana C, Alvarez-Miguel I, Pérez-GNAGORE DE PABLO HERRANZLeptolide Improves Insulin Resistance in Diet-Induced Obese Mice.PABLO VILLA PEREZMar Drugs. 2017 Sep 15;15(9). pii: E289. doi: 10.3390/md15090289. "Pharynx mitochondrial [Ca2+] dynamics in live c.elegans worms during aging"PALOMA GARCÍA CASASProtecting cells by protecting their vulnerable lysosomes: Identification of a new mechanism for preserving lysosomal functional integrity upon oxidatRAQUEL PASCUA MAESTROPascua-Maestro R, Diez-Hermano S, Lillo C, Ganfornina MD, Sanchez D. PLoS Genet. 2017 Feb 9;13(2):e1006603. Doi: 10.1371/journal.pgen.1006603 . Fungal pattern recepors down-regulate the inflammatoy response by a cross-inhibitory mechanism independent of IL-10 production.Saioa Márquez PiñeiroEndoplasmic reticulum stress sensor IRE1¿ enhances IL-23 expression by human dendritic cellsSaioa Márquez PiñeiroBiomedical Applications of Recombinant Proteins and Derived Polypeptides "Biopolymers for Medical Applications - CRC Press Book" ISBN 9781498744966SOFIA SERRANO DUCAR2015/2016Modulation of brain network parameters associated with subclinical psychotic symptomsALBA LUBEIRO JUÁREZArtículos: Progress in Neuro-Psychopharmacology & Biological Psychiatry Elevated midline parietal gamma band noise power in schizophrenia but not in bipolar patientsALBA LUBEIRO JUÁREZRevista: European archives of Psychiatry and Clinical Neurosciences Identification of two clusters within schizophrenia with different structural, functional and clinical characterALBA LUBEIRO JUÁREZRevista: Progress in Neuro-Psychopharmacology & Biological Psychiatry Encyclopedia of Biomedical Polymers and Polymeric Biomaterials (EBPP).Taylor and Francis, 2014ALICIA FERNANDEZ COLINOElastin-like Recombinamers Biomacromolecules. 15 - 10, pp. 3781 - 3793. 2014ALICIA FERNANDEZ COLINOSelf-Organized ECM-Mimetic Model Based on an Amphiphilic Multiblock Silk-Elastin-Like Corecombinamer Biomacromolecules. 16 - 10, pp. 3389 - 3398. 2015ALICIA FERNANDEZ COLINOAmphiphilic Elastin-Like Block Co-Recombinamers Containing Leucine Zippers Biotechnology Journal. 6, pp. 1 - 13. 2011ALICIA FERNANDEZ COLINOElastin-like Recombinamers: Biosynthetic Strategies and Biotechnological Applications Advances in Biochemical Engineering/Biotechnology. Biofunctionalisation, pp. 1 - 35. Springer, 2010ALICIA FERNANDEZ COLINORecombinamers: Combining Molecular Complexity with Diverse Bioactivities for Advanced Biomedical and Biotechnological Applications Current Topics in Medicinal Chemistry. 14, pp. 819 - 836. 2014ALICIA FERNANDEZ COLINORecent contributions of elastin-like recombinamers to biomedicine and nanotechnology Biomecánica. pp. 37 - 45. 2011ALICIA FERNANDEZ COLINOLos polímeros tipo elastina y su utilización como tags para la purificación de proteínas. Biomaterials Surface Science. pp. 239 - 268. Wiley-VCH Verlag GmbH & Co. KGaA, 2013ALICIA FERNANDEZ COLINOBioactive and Smart Hydrogel Surfaces Bioconjugate Chemistry. 26 - 7, pp. 1252 - 1265. 2015.ALICIA FERNANDEZ COLINONanotechnological Approaches to Therapeutic Delivery Using Elastin-Like Recombinamers Elastin-like recombinamers as smart drug delivery systemsARTURO IBAÑEZ FONSECANanotechnological Approaches to Therapeutic Delivery Using Elastin-Like RecombinamersARTURO IBAÑEZ FONSECARecombinant Technology in the Development of Materials and Systems for Soft-Tissue RepairARTURO IBAÑEZ FONSECAPhospholipid sources for adrenic acid mobilization in RAW 264.7 macrophages. Comparison with arachidonic acidCARLOS GUIJAS MATEBiochimica et Biophysica Acta, 1821:1386-1393. Group V secreted phospholipase A2 is up-regulated by interleukin-4 in human macrophages and mediates phagocytosis via hydrolysis of ethanolamine phospCARLOS GUIJAS MATEJournal of Immunology, 194: 3327-3339. Opposite cross-talk by oleate and palmitate on insulin signaling in hepatocytes through macrophage activationCARLOS GUIJAS MATEJournal of Biological Chemistry, 290:11663-77. Cytosolic group IVA and calcium-independent group VIA phospholipases A2 act on distinct phospholipid pools in zymosan-stimulated mouse peritoneal macrCARLOS GUIJAS MATEJournal of Immunology, 192: 752-762. Lipin-1 integrates lipid synthesis with proinflammatory responses during TLR activation in macrophagesCARLOS GUIJAS MATEJournal of Immunology, 193: 4614-4622. Influence of Cellular Arachidonic Acid Levels on Phospholipid Remodeling and CoA-independent Transacylase Activity in Human Monocytes and U937 CellsCARLOS GUIJAS MATEBiochimica et Biophysica Acta, 1811: 97-103 Subcellular localization and role of lipin-1 in human macrophagesCARLOS GUIJAS MATEJournal of Immunology, 186: 6004-6013 Simultaneous Activation of p38 and JNK by Arachidonic Acid Stimulates the Cytosolic Phospholipase A2-dependent Synthesis of Lipid Droplets in Human MoCARLOS GUIJAS MATEJournal of Lipid Research, 53: 2343¿2354 A phosphatidylinositol species acutely generated by activated macrophages regulates innate immune responsesCARLOS GUIJAS MATEJournal of Immunology, 190: 5169-5177 Phospholipase A2 regulation of lipid droplet formationCARLOS GUIJAS MATEBiochim. Biophys. Acta, 1841: 1661-1671. Título `Advanced systems for controlled drug delivery from chemically modified Elastin-like Recombinamers`. Autores: Mercedes Santos, Constancio GonzáEDUARDO PEREZ DEL RIORed Ear and More: Facial and Extrafacial Erythema Accompanying Migraine Attacks.ELENA MARTINEZ VELASCOPublicación en revista internacional. Headache with transient neurological deficit: a case report with hemispheric hypoperfusion and without lymphocytosis.ELENA MARTINEZ VELASCOPublicación en revista internacional. Confusional state in HaNDL syndrome: an uncommon clinical manifestation.ELENA MARTINEZ VELASCOPublicación en revista internacional. Meana, C., L. Pena, G. Lorden, E. Esquinas, C. Guijas, M. Valdearcos, J. Balsinde, and M. A. Balboa. 2014. Lipin-1 integrates lipid synthesis with proGEMA LORDEN LOSADALaura Jiménez Pérez et al. "Molecular determinants of Kv1.3 potassium channels-induced proliferation". Journal of Biological Chemistry. 2016 Feb 12;2INÉS ÁLVAREZ MIGUELEmbryonic cerebrospinal fluid in brain development: neural progenitor controlJose Francisco Lamus MolinaCroat Med J. 2014 Aug 28;55(4):299-305. (Q2 IF: 1.305) Retinoic Acid, under Cerebrospinal Fluid Control, Induces Neurogenesis during Early Brain DevelopmentJose Francisco Lamus MolinaJ Dev Biol. 2014;2(2):72-83. (Indexada: Emerging Sources Citation Index (ESCI ¿ Web of Science) ISSN 2221-3759 Embryonic cerebrospinal fluid activates neurogenesis of neural precursors within the subventricular zone of the adult mouse brainJose Francisco Lamus MolinaCells Tissues Organs. 2013;198(5):398-404. (Q1 IF: 2.137) Navas-Navarro P, Rojo-Ruiz J, Rodriguez-Prados M, Ganfornina MD1, Looger LL, Alonso MT, García-Sancho J.MACARENA RODRIGUEZ VALLEGFP-Aequorin Protein Sensor for Ex Vivo and In Vivo Imaging of Ca(2+) Dynamics in High-Ca(2+) Organelles.Cell Chem Biol. 2016 Jun 23;23(6):738-45 López-Doménech et al., 2012MACARENA RODRIGUEZ VALLEThe Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2. Nat Commun. 8;3:814 Rodríguez-Prados M., Rojo-Ruiz J., Aulestia F.J., García-Sancho J., Alonso M.T. (2015) A new low-Ca(2+) affinity GAP indicator to monitor high Ca(2+)MACARENA RODRIGUEZ VALLEClinical description, pathophysiological approach, and a new therapeutic option.Neurologia. 2016 Jan 6. pii: S0213-4853(15)00247-9MARIA ISABEL PEDRAZA HUESOHeadache with transient neurological deficit: a case report with hemispheric hypoperfusion and without lymphocytosis.Neurol Sci. 2016 Apr 25MARIA ISABEL PEDRAZA HUESORodríguez-Cabello, J.C., et al., Elastin-Like Recombinamers, in Encyclopedia of Biomedical Polymers and Polymeric Biomaterials. 2016, Taylor and FrancMARIA JESUS PIÑA LANCHOJose C. Rodríguez Cabello et al. Nanotechnological Approaches to Therapeutic Delivery Using Elastin-Like Recombinamers. Bioconjugate chemistry.26 - 7MARIA JESUS PIÑA LANCHOSegundo autor Maria J. Piña Rodríguez-Cabello, J.C., et al., Bioactive and Smart Hydrogel Surfaces, in Biomaterials Surface Science. 2013, Wiley-VCH Verlag GmbH & Co. KGaA. p. 23MARIA JESUS PIÑA LANCHOCapítulo libro Maria J. Piña et al. Elastin-like recombinamers with acquired functionalities for gene-delivery applications. Journal of Biomedical ResearchA. 10-103MARIA JESUS PIÑA LANCHOPrimer autor. Maria J. Piña Piña, M.J., et al., Biocompatible ELR-Based Polyplexes Coated with MUC1 Specific Aptamers and Targeted for Breast Cancer Gene Therapy. Molecular PharmMARIA JESUS PIÑA LANCHOMaria J. Piña como primer autor Brief Research Report Auriculotemporal Neuralgia: Eight New Cases ReportMARINA RUIZ PIÑEROThe dynamics of mitochondrial Ca2+ fluxes. (2010) Biochim Biophys Acta. 1797, 1727-1735. ISSN 0006-3002.PABLO MANUEL MONTENEGRO ESCUDERODe la Fuente, S., Montenegro, P., Fonteriz, R.I., Moreno, A., Lobatón, C.D., Montero, M., and Álvarez, J. (2010) Biochim Biophys Acta. 1797, 1727-1735 In vivo Ca2+ imaging in the endoplasmic reticulum with an optimized GFP-aequorin sensor. Paloma Navas-Navarro, Jonathan Rojo-Ruiz, Macarena Rodriguez-PALOMA NAVAS NAVARROEn revisión. GAP, an aequorin-based fluorescent indicator for imaging Ca2+ in organelles. Arancha Rodriguez-Garcia, Jonathan Rojo-Ruiz, Paloma Navas-Navarro, FrancPALOMA NAVAS NAVARROPharmacological inhibition of eicosanoids and platelet-activating factor signaling impairs zymosan-induced release of IL-23 by dendritic cellsSaioa Márquez PiñeiroElastin-like recombinamers as smart drug delivery systems. "Current Drug Targets Volume 17, 16 Issues, 2016"SOFIA SERRANO DUCARCapitulo de un libroTatjana FloraBook Chapter CRCPress/Taylor&Francis Biopolymer for medical Applications 2013/2014EN REVISIÓN:¿Aging without Apolipoprotein D: Molecular and cellular modifications in the hippocampus and cortex¿RAQUEL PASCUA MAESTRODiego Sánchez. Raquel Bajo-Grañeras, Manuela del Caño-Espinel, Rosa García-Centeno, Nadia García-Mateo, Raquel Pascua-Maestro, Maria Ganfornina. |