Theses defended

2024/2025

Papel de la enzima degradadora de insulina (IDE) en el metabolismo hepático

Author: Patricia Cámara Torres
Director/s: German Manuel Perdomo Hernandez, Andres Alonso Garcia
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 13/12/2024

DEVELOPMENT OF NOVEL WOUND DRESSING BASED ON ELASTIN-LIKE RECOMBINAMERS FOR SKIN REGENERATION

Author: Diana Juanes Gusano
Director/s: Jose Carlos Rodriguez Cabello, Maria Mercedes Santos Garcia
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 25/10/2024
International doctorate mention

2023/2024

Kv1.3 channels and vascular smooth muscle phenotypic modulation: A new therapeutical target for vascular diseases

Author: Sara Moreno Estar
Director/s: Maria Teresa Perez Garcia, Maria Del Pilar Cidad Velasco
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 05/07/2024
International doctorate mention

New insights into the role of mitochondrial respiration in macrophage functions

Author: Dino Joaquín Gobelli
Director/s: Miguel Angel De La Fuente Garcia, Maria Simarro Grande
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 19/04/2024
International doctorate mention

REMODELADO DEL CALCIO INTRACELULAR EN EL ENVEJECIMIENTO NEURONAL Y LOS TUMORES CEREBRALES

Author: María Elena Hernando Pérez
Director/s: Lucia Nuñez Llorente, Carlos Villalobos Jorge
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 12/04/2024

Estudio del remodelado iónico en cáncer de colon mediante la transferencia mitocondrial y la inhibición de la síntesis de poliaminas.

Author: Verónica Feijóo Salgado
Director/s: Carlos Villalobos Jorge, Sendoa Tajada Esteban
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 22/03/2024

Remodeling of G protein coupled receptors signaling pathways in essential hypertension

Author: Nuria Daghbouche Rubio
Director/s: Maria Teresa Perez Garcia, Jose Ramon Lopez Lopez
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 08/03/2024
International doctorate mention

Alteración de los patrones de splicing en genes de susceptibilidad a cáncer de mama: análisis funcional mediante minigenes híbridos.

Author: Lara Sanoguera Miralles
Director/s: Eladio Andrés Velasco Sampedro
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 23/02/2024
Theses by compendium of publications

Role of insulin-degrading enzyme in pancreatic alpha-cell function.

Author: Elena Casanueva Álvarez
Director/s: Irene Cozar Castellano, Safia Costes
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 02/02/2024
International doctorate mention

Lipid Rafts in brain cells: From enzymatic activity to lipidomic assays in a novel printed Rafts platform

Author: Laura Sanchez Sanchez
Director/s: Maria Dolores Ganfornina Alvarez, Gabriel Barreda Gómez
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 18/12/2023
Industrial doctorate mention
International doctorate mention

METABOLIC REWIRING IS REQUIRED FOR INFLAMMATION, CALCIFICATION, AND OSTEOGENIC DIFFERENTIATION OF HUMAN AORTIC VALVE INTERSTITIAL CELLS EXPOSED TO AN INFLAMMATORY MILIEU, AND MIMICS THE METABOLIC PHENOTYPE IN CALCIFIED AORTIC VALVES

Author: Tania Sánchez-Bayuela Recio
Director/s: Maria Del Carmen Garcia Rodriguez
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 15/12/2023
International doctorate mention

Estudios lipidómicos en macrófagos. Regulación de los niveles lipídicos por lipinas y su impacto en la biología del macrófago y en procesos inflamatorios

Author: Álvaro Garrido Jiménez
Director/s: Maria Angeles Balboa García, Jesús Balsinde Rodríguez
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 22/11/2023

Characterization of endogenous Kv1.3 channel isoforms in T cells.

Author: Julia Serna Perez
Director/s: Miguel Angel De La Fuente Garcia, Maria Teresa Perez Garcia
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 06/10/2023
International doctorate mention

2022/2023

The IRE1-XBP1 Branch of the Unfolded Protein Response Underpins Cytokine Induction and Viral Replication in SARS-CoV-2 Infection

Author: Jose Javier Fernandez Rodriguez
Director/s: Maria Nieves Fernandez Garcia, Mariano Sanchez Crespo
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 09/06/2023
International doctorate mention

La reprogramación metabólica inducida por patrones moleculares de la pared fúngica regula la expresión de citoquinas

Author: Cristina Mancebo Tejera
Director/s: Mariano Sanchez Crespo, Maria Nieves Fernandez Garcia
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 14/04/2023

Análisis lipidómico de los cambios en el metabolismo lipídico que tienen lugar durante la activación de los macrófagos peritoneales de ratón por estímulos proinflamatorios

Author: Patricia Monge Bartolomé
Director/s: Jesús Balsinde Rodríguez, Maria Angeles Balboa García
Qualification: SOBRESALIENTE
Reading date: 07/12/2022

Hepatic insulin-degrading enzyme regulation and its role on glucagon signaling

Author: Carlos Manuel González Casimiro
Director/s: Irene Cozar Castellano, German Manuel Perdomo Hernandez
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 29/11/2022
International doctorate mention

2021/2022

Estudio lipidómico de la activación y maduración de células dendríticas. Efecto del ácido araquidónico y de los isómeros del ácido hexadecenoico

Author: LAURA PEREIRA DE BLAS
Director/s: Jesús Balsinde Rodríguez, Maria Angeles Balboa García
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 14/07/2022

Desregulación del splicing del gen PALB2 en cáncer de mama hereditario

Author: ALBERTO VALENZUELA PALOMO
Director/s: Eladio Andrés Velasco Sampedro
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 29/04/2022

Análisis Transcriptómico del Remodelado del Calcio Intracelular en Cáncer de Colon

Author: ENRIQUE PÉREZ RIESGO
Director/s: Carlos Villalobos Jorge
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 04/03/2022

The insulin-degrading enzyme: from molecular evolution and subcellular localization to new roles in microglial physiology

Author: MIRIAM CORRALIZA GOMEZ
Director/s: Maria Dolores Ganfornina Alvarez, Irene Cozar Castellano, Eduardo Arranz Sanz
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 01/12/2021
International doctorate mention

2020/2021

Regulación de la respuesta inflamatoria de las células fagocíticas por lípidos: Papel del ácido araquidónico y de los isómeros del ácido palmitoleico

Author: MIGUEL ANGEL BERMUDEZ ARIAS
Director/s: Jesús Balsinde Rodríguez, Maria Angeles Balboa García
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 28/05/2021

Development of advanced modular molecules for innovative devices in delivery of therapeutic agents

Author: SOFIA SERRANO DUCAR
Director/s: Francisco Javier Arias Vallejo, Alessandra Girotti
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 25/03/2021

Marcadores granulocíticos para diagnóstico, estratificación de gravedad y pronóstico en la infección.

Author: MARTA MARTIN FERNÁNDEZ
Director/s: Jesus Francisco Bermejo Martin, Raquel Almansa Mora
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 18/01/2021

Órgano especificidad de los biomarcadores de sepsis

Author: CRISTINA ANDRES LEDESMA
Director/s: Jesus Francisco Bermejo Martin, David Andaluz Ojeda
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 15/01/2021

El Colágeno tipo XIII en la patogenia de la estenosis aórtica calcificada

Author: IRENE CASTAÑOS-MOLLOR MORCILLO
Director/s: Maria Del Carmen Garcia Rodriguez
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 18/11/2020

2019/2020

Sarcoplasmic reticulum calcium dynamics in aging and correlation with sarcopenia

Author: ALBA DEL RÍO LORENZO
Director/s: Maria Teresa Alonso Alonso, Francisco Javier Garcia Sancho Martin
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 25/09/2020
International doctorate mention

Development of biomaterials based on elastin like recombinamers for 3d bioprinting applications

Author: SORAYA SALINAS FERNÁNDEZ
Director/s: Jose Carlos Rodriguez Cabello, Maria Mercedes Santos Garcia
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 25/09/2020

Use of Kv1.3 channel blockers for the prevention of restenosis in human vessels: Mechanisms and outcomes in diabetic patients

Author: MARYCARMEN ARÉVALO MARTÍNEZ
Director/s: Maria Teresa Perez Garcia, Maria Del Pilar Cidad Velasco
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 11/09/2020
International doctorate mention

Calcium signaling modulators: a novel pharmacological intervention to delay aging in Caenorhabditis elegans

Author: PALOMA GARCÍA CASAS
Director/s: Javier Alvarez Martin, Maria Teresa Montero Zoccola, Rosalba Ines Fonteriz Garcia
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 11/09/2020
International doctorate mention

LA ATROFIA CEREBRAL COMO PREDICTOR DE REPERFUSIÓN ENDOVASCULAR FÚTIL EN EL INFARTO CEREBRAL AGUDO DE CIRCULACIÓN ANTERIOR

Author: MARIA ISABEL PEDRAZA HUESO
Director/s: Juan Francisco Arenillas Lara
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 10/07/2020

Self-assembling nanosystems based on elastin-like recombinamers and antimicrobial peptides for biomedical applications

Author: Sergio Acosta Rodríguez
Director/s: Jose Carlos Rodriguez Cabello
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 19/02/2020
International doctorate mention

Phospholipid Arachidonic Acid Remodeling in Macrophages: Role of Plasmalogen Species.

Author: PATRICIA LEBRERO FERNÁNDEZ
Director/s: Jesús Balsinde Rodríguez, Maria Angeles Balboa García
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 22/11/2019
International doctorate mention

Modulation of Macrophage Antiviral Responses by Lipin-2: Type I Interferon, Inflammasome and Cholesterol Homeostasis

Author: NAGORE DE PABLO HERRANZ
Director/s: Maria Angeles Balboa García, Jesús Balsinde Rodríguez
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 18/11/2019
International doctorate mention

Lipin-2 regulates palmitic acid-induced inflammasome NLRP3 activation in macrophages

Author: MIREN ITZIAR SANJUAN GARCIA
Director/s: Maria Angeles Balboa García, Jesús Balsinde Rodríguez
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 15/11/2019
International doctorate mention

Potencial terapéutico de antioxidantes sintéticos y naturales en la prevención de alteraciones asociadas a la miocarditis: estudio en un modelo de miocarditis autoinmune experimental

Author: ISABEL GALLARDO ROMERO
Director/s: Maria Luisa Nieto Callejo
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 08/11/2019

Calcium channel remodeling in colon cancer cells: Implications for channel inactivation and reversal by polyamine synthesis inhibition

Author: LUCÍA GONZÁLEZ GUTIÉRREZ
Director/s: Carlos Villalobos Jorge, Lucia Nuñez Llorente
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 04/11/2019
International doctorate mention

EFFECTS OF INTERFERONS AND THEIR INTERACTIONS WITH OTHER LIGANDS IN HUMAN AORTIC VALVE CELLS

Author: IVÁN PARRA IZQUIERDO
Director/s: Maria Del Carmen Garcia Rodriguez
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 07/10/2019
International doctorate mention

Engineering responsive and biomimetic material based on Elastin-like Recombinamers for biomedical application

Author: Filippo Cipriani
Director/s: Jose Carlos Rodriguez Cabello, Israel Gonzalez De Torre
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 04/10/2019
Theses by compendium of publications
International doctorate mention

2018/2019

Regulación de la transcripción de citoquinas por la modulación del metabolismo energético y el estrés del retículo endoplasmático en células dendríticas

Author: Saioa Márquez Piñeiro
Director/s: Mariano Sanchez Crespo, Maria Nieves Fernandez Garcia
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 29/07/2019

Role of insulin-degrading enzyme (IDE) in pancreatic beta-cell function: relevance in health and diabetes mellitus

Author: Cristina María Fernández Díaz
Director/s: Irene Cozar Castellano, German Manuel Perdomo Hernandez
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 26/07/2019
International doctorate mention

PROPIEDADES TERAPÉUTICAS DE SECOIRIDOIDES Y TRITERPENOS. ESTUDIO EN UN MODELO EXPERIMENTAL DE ESCLEROSIS MÚLTIPLE.

Author: BEATRIZ ROSA GUTIERREZ MIRANDA
Director/s: Maria Luisa Nieto Callejo
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 19/07/2019

BIOENGINEERED DYNAMIC SYSTEMS BASED ON ELASTIN-LIKE RECOMBINAMERS

Author: Tatjana Flora
Director/s: Jose Carlos Rodriguez Cabello
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 26/06/2019
Theses by compendium of publications
International doctorate mention

Functions of sensory TRP channels in vascular responses to chemical and thermal stimuli

Author: LUCÍA ALONSO CARBAJO
Director/s: Maria Teresa Perez Garcia, Karel Talavera Perez
Qualification: SOBRESALIENTE
Reading date: 20/06/2019
Co-supervised thesis

TRANSCRIPCIÓN Y SPLICING DE BRCA2 Y SU RELACIÓN CON LA SUSCEPTIBILIDAD A CÁNCER DE MAMA Y OVARIO HEREDITARIO.

Author: MARIA EUGENIA FRAILE BETHENCOURT
Director/s: Eladio Andrés Velasco Sampedro
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 31/05/2019
Theses by compendium of publications

Remodeling of vascular smooth muscle ion channels involved in purinergic signaling in essential hypertension

Author: INÉS ÁLVAREZ MIGUEL
Director/s: Maria Teresa Perez Garcia, Jose Ramon Lopez Lopez
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 08/04/2019
International doctorate mention

Efectos inducidos por la hipoxia crónica intermitente en rata y cobaya como modelos animales de la apnea obstructiva del sueño

Author: MARÍA INMACULADA DOCIO CUADRADO
Director/s: Maria Asuncion Rocher Martin, Jesus Prieto Lloret
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 01/03/2019

Detección, análisis y clasificación de variantes genéticas en el diagnóstico molecular del cáncer hereditario

Author: CAROLINA VELÁZQUEZ PÉREZ
Director/s: Maria Del Carmen Dominguez Lobaton, Maria Del Mar Infante Sanz, Maria Mercedes Duran Dominguez
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 18/02/2019

BIOLOGICALLY RELEVANT SUBGROUPS WITHIN THE SCHIZOPHRENIA SYNDROME

Author: ALBA LUBEIRO JUÁREZ
Director/s: Vicente Molina Rodriguez
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 18/01/2019
Theses by compendium of publications
International doctorate mention

EFFECTS OF AMP-ACTIVATED KINASE MODULATORS ON INTRACELLULAR Ca2+ SIGNALLING AND C. ELEGANS LIFESPAN

Author: JESICA ARIAS DEL VAL
Director/s: Javier Alvarez Martin, Rosalba Ines Fonteriz Garcia, Maria Teresa Montero Zoccola
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 27/11/2018
International doctorate mention

IDENTIFICATION OF A NEW MECHANISM FOR PRESERVING LYSOSOMAL FUNCTIONAL INTEGRITY UPON OXIDATIVE STRESS.

Author: RAQUEL PASCUA MAESTRO
Director/s: Maria Dolores Ganfornina Alvarez, Diego Sanchez Romero
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 15/10/2018
International doctorate mention

2017/2018

CALCIUM DYNAMICS IN CAENORHABDITIS ELEGANS PHARYNX

Author: MARIA PILAR ALVAREZ ILLERA
Director/s: Maria Teresa Montero Zoccola, Javier Alvarez Martin, Rosalba Ines Fonteriz Garcia
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 28/09/2018
International doctorate mention

ROLE OF INSULIN-DEGRADING ENZYME (IDE) IN DIABETES MELLITUS AND INSULIN RESISTANCE.

Author: PABLO VILLA PEREZ
Director/s: Irene Cozar Castellano, German Manuel Perdomo Hernandez, Maria Del Carmen Dominguez Lobaton
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 12/01/2018

DINÁMICA DEL CALCIO RETICULAR EN ASTROCITOS CORTICALES.

Author: MACARENA RODRIGUEZ VALLE
Director/s: Maria Teresa Alonso Alonso, Francisco Javier Garcia Sancho Martin
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 27/11/2017

NOVEL HYDROGEL-FORMING ELASTIN-LIKE RECOMBINAMERS FOR BIOMEDICAL APPLICATIONS

Author: ARTURO IBAÑEZ FONSECA
Director/s: Francisco Javier Arias Vallejo, Matilde Alonso Rodrigo
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 24/11/2017
Theses by compendium of publications
International doctorate mention

2016/2017

EL PAPEL DEL CALCIO INTRAVESICULAR EN LA SECRECIÓN CELULAR DE LÍNEAS NEUROENDOCRINAS.

Author: PABLO MANUEL MONTENEGRO ESCUDERO
Director/s: Alfredo Miguel Moreno Diaz Calderon, Javier Alvarez Martin, Maria Del Carmen Dominguez Lobaton
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 14/12/2016

2015/2016

EL FGF2 COMO REGULADOR DE LA ACTIVIDAD MITOGÉNICA DE PRECURSORES NEURALES EN EL NICHO CELULAR DEL CEREBRO EMBRIONARIO DE RATÓN. Presentada

Author: Jose Francisco Lamus Molina
Director/s: Angel Luis Gato Casado
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 30/09/2016

ENVEJECIMIENTO Y EFECTOS DE LA HIPOXIA INTERMITENTE CRÓNICA SOBRE TUMORIGÉNESIS ESPONTÁNEA DE RATÓN.

Author: MARIA TERESA GALLEGO MARTIN
Director/s: Ana Maria De La Luz Obeso Caceres, Maria Asuncion Rocher Martin
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 26/07/2016
International doctorate mention

REGULACIÓN DE LA ACTIVACIÓN DEL INFLAMASOMA NLRP3 POR LIPINA-2 EN MACRÓFAGOS.

Author: GEMA LORDEN LOSADA
Director/s: Maria Angeles Balboa García, Jesús Balsinde Rodríguez
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 11/07/2016
International doctorate mention

DISEÑO DE UN NUEVO SENSOR DE CA2+ Y SU APLICACIÓN A LOS ORGÁNULOS INTRACELULARES EX VIVO E IN VIVO.

Author: PALOMA NAVAS NAVARRO
Director/s: Maria Teresa Alonso Alonso, Francisco Javier Garcia Sancho Martin
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 08/07/2016
International doctorate mention

ELR-BASES NANOCOMPLEXES WITH POTENTIAL BIOMEDICAL USES

Author: MARIA JESUS PIÑA LANCHO
Director/s: Francisco Javier Arias Vallejo, Jose Carlos Rodriguez Cabello
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 24/06/2016
International doctorate mention

REGULACIÓN DE LA FORMACIÓN DE GOTAS LIPÍDICAS POR ÁCIDO ARAQUIDÓNICO EN MONOCITOS HUMANOS: IMPORTANCIA DEL ÁCIDO GRASO 16: 1N-9

Author: CARLOS GUIJAS MATE
Director/s: Jesús Balsinde Rodríguez, Maria Angeles Balboa García
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 18/03/2016
International doctorate mention

THERMOSENSITIVE INJECTABLE HYDROGELS WITH ENHANCED STABILITY BASED ON ELASTIN, SILK AND LEUCINE ZIPPER MOTIFS FOR TISSUE ENGINEERING AND DRUG DELIVERY APPLICATIONS.

Author: ALICIA FERNANDEZ COLINO
Director/s: Francisco Javier Arias Vallejo, Matilde Alonso Rodrigo
Qualification: SOBRESALIENTE CUM LAUDE
Reading date: 22/02/2016
International doctorate mention